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A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, Lp Benesch J. Alderson TR, et al. Among authors: baldwin aj. EMBO J. 2021 Apr 15;40(8):e103811. doi: 10.15252/embj.2019103811. Epub 2021 Mar 1. EMBO J. 2021. PMID: 33644875 Free PMC article.
Local unfolding of the HSP27 monomer regulates chaperone activity.
Alderson TR, Roche J, Gastall HY, Dias DM, Pritišanac I, Ying J, Bax A, Benesch JLP, Baldwin AJ. Alderson TR, et al. Among authors: baldwin aj. Nat Commun. 2019 Mar 6;10(1):1068. doi: 10.1038/s41467-019-08557-8. Nat Commun. 2019. PMID: 30842409 Free PMC article.
Proline isomerization in the C-terminal region of HSP27.
Alderson TR, Benesch JLP, Baldwin AJ. Alderson TR, et al. Among authors: baldwin aj. Cell Stress Chaperones. 2017 Jul;22(4):639-651. doi: 10.1007/s12192-017-0791-z. Epub 2017 May 25. Cell Stress Chaperones. 2017. PMID: 28547731 Free PMC article.
Conditional Disorder in Small Heat-shock Proteins.
Alderson TR, Ying J, Bax A, Benesch JLP, Baldwin AJ. Alderson TR, et al. Among authors: baldwin aj. J Mol Biol. 2020 Apr 17;432(9):3033-3049. doi: 10.1016/j.jmb.2020.02.003. Epub 2020 Feb 17. J Mol Biol. 2020. PMID: 32081587 Free PMC article.
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.
Collier MP, Alderson TR, de Villiers CP, Nicholls D, Gastall HY, Allison TM, Degiacomi MT, Jiang H, Mlynek G, Fürst DO, van der Ven PFM, Djinovic-Carugo K, Baldwin AJ, Watkins H, Gehmlich K, Benesch JLP. Collier MP, et al. Among authors: baldwin aj. Sci Adv. 2019 May 22;5(5):eaav8421. doi: 10.1126/sciadv.aav8421. eCollection 2019 May. Sci Adv. 2019. PMID: 31131323 Free PMC article.
Small heat-shock proteins: paramedics of the cell.
Hilton GR, Lioe H, Stengel F, Baldwin AJ, Benesch JL. Hilton GR, et al. Among authors: baldwin aj. Top Curr Chem. 2013;328:69-98. doi: 10.1007/128_2012_324. Top Curr Chem. 2013. PMID: 22576357 Review.
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.
Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. Hochberg GK, et al. Among authors: baldwin aj. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1562-70. doi: 10.1073/pnas.1322673111. Epub 2014 Apr 7. Proc Natl Acad Sci U S A. 2014. PMID: 24711386 Free PMC article.
122 results