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(+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice.
González-Mariscal I, Carmona-Hidalgo B, Winkler M, Unciti-Broceta JD, Escamilla A, Gómez-Cañas M, Fernández-Ruiz J, Fiebich BL, Romero-Zerbo SY, Bermúdez-Silva FJ, Collado JA, Muñoz E. González-Mariscal I, et al. Among authors: collado ja. Pharmacol Res. 2021 Jul;169:105492. doi: 10.1016/j.phrs.2021.105492. Epub 2021 May 19. Pharmacol Res. 2021. PMID: 34019978
The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways.
del Río C, Navarrete C, Collado JA, Bellido ML, Gómez-Cañas M, Pazos MR, Fernández-Ruiz J, Pollastro F, Appendino G, Calzado MA, Cantarero I, Muñoz E. del Río C, et al. Among authors: collado ja. Sci Rep. 2016 Feb 18;6:21703. doi: 10.1038/srep21703. Sci Rep. 2016. PMID: 26887982 Free PMC article.
Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives.
Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR, Holzgrabe U. Götz MR, et al. Among authors: collado ja. Front Pharmacol. 2019 Nov 20;10:1284. doi: 10.3389/fphar.2019.01284. eCollection 2019. Front Pharmacol. 2019. PMID: 31824305 Free PMC article.
Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors.
Palomares B, Garrido-Rodriguez M, Gonzalo-Consuegra C, Gómez-Cañas M, Saen-Oon S, Soliva R, Collado JA, Fernández-Ruiz J, Morello G, Calzado MA, Appendino G, Muñoz E. Palomares B, et al. Among authors: collado ja. Br J Pharmacol. 2020 Sep;177(17):4034-4054. doi: 10.1111/bph.15155. Epub 2020 Jul 8. Br J Pharmacol. 2020. PMID: 32510591 Free PMC article.
"Photo-Rimonabant": Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar "Cis-On" CB1R Antagonist.
Rodríguez-Soacha DA, Fender J, Ramírez YA, Collado JA, Muñoz E, Maitra R, Sotriffer C, Lorenz K, Decker M. Rodríguez-Soacha DA, et al. Among authors: collado ja. ACS Chem Neurosci. 2021 May 5;12(9):1632-1647. doi: 10.1021/acschemneuro.1c00086. Epub 2021 Apr 15. ACS Chem Neurosci. 2021. PMID: 33856764 Free PMC article.
Effect of N-acyl-dopamines on beta cell differentiation and wound healing in diabetic mice.
Jiménez-Jiménez C, Lara-Chica M, Palomares B, Collado JA, Lopez-Miranda J, Muñoz E, Calzado MA. Jiménez-Jiménez C, et al. Among authors: collado ja. Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt A):1539-1551. doi: 10.1016/j.bbamcr.2018.08.008. Epub 2018 Aug 16. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 30327197 Free article.
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