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Most adults with severe HbSC disease are not treated with hydroxyurea.
Ghunney WK, Asare EV, Ayete-Nyampong JB, Oppong SA, Rodeghier M, DeBaun MR, Olayemi E. Ghunney WK, et al. Among authors: rodeghier m. Blood Adv. 2023 Jul 11;7(13):3312-3319. doi: 10.1182/bloodadvances.2022009049. Blood Adv. 2023. PMID: 36799926 Free PMC article.
Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.
Thangarajh M, Yang G, Fuchs D, Ponisio MR, McKinstry RC, Jaju A, Noetzel MJ, Casella JF, Barron-Casella E, Hooper WC, Boulet SL, Bean CJ, Pyle ME, Payne AB, Driggers J, Trau HA, Vendt BA, Rodeghier M, DeBaun MR. Thangarajh M, et al. Among authors: rodeghier m. Br J Haematol. 2012 Nov;159(3):352-9. doi: 10.1111/bjh.12034. Epub 2012 Sep 7. Br J Haematol. 2012. PMID: 22958163 Free PMC article. Clinical Trial.
Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction.
Dowling MM, Noetzel MJ, Rodeghier MJ, Quinn CT, Hirtz DG, Ichord RN, Kwiatkowski JL, Roach ES, Kirkham FJ, Casella JF, DeBaun MR. Dowling MM, et al. Among authors: rodeghier mj. J Pediatr. 2014 May;164(5):1175-1180.e1. doi: 10.1016/j.jpeds.2014.01.001. Epub 2014 Feb 13. J Pediatr. 2014. PMID: 24529619 Free PMC article. Clinical Trial.
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