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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes.
Pinch BJ, Buckley DL, Gleim S, Brittain SM, Tandeske L, D'Alessandro PL, Hauseman ZJ, Lipps J, Xu L, Harvey EP, Schirle M, Sprague ER, Forrester WC, Dovala D, McGregor LM, Thoma CR. Pinch BJ, et al. Among authors: d alessandro pl. Cell Chem Biol. 2022 Jan 20;29(1):57-66.e6. doi: 10.1016/j.chembiol.2021.08.007. Epub 2021 Sep 8. Cell Chem Biol. 2022. PMID: 34499862 Free article.
Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo.
Karatas H, Maric T, D'Alessandro PL, Yevtodiyenko A, Vorherr T, Hollingworth GJ, Goun EA. Karatas H, et al. Among authors: d alessandro pl. ACS Chem Biol. 2019 Oct 18;14(10):2197-2205. doi: 10.1021/acschembio.9b00439. Epub 2019 Sep 24. ACS Chem Biol. 2019. PMID: 31498986
Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension.
Shaw DE, Smith N, Beerli R, Cotesta S, D'Alessandro PL, Edwards AM, Lattmann R, Lizos D, Pulz R, Rooney L, Sohal B, Rynn C, Taylor J, Troxler T, Williams G, Guth S, Rowlands D. Shaw DE, et al. Among authors: d alessandro pl. J Med Chem. 2023 Jun 22;66(12):8130-8139. doi: 10.1021/acs.jmedchem.3c00229. Epub 2023 Jun 9. J Med Chem. 2023. PMID: 37294287
Evaluating Cellular Drug Uptake with Fluorescent Sensor Proteins.
Scarabelli S, Tan KT, Griss R, Hovius R, D'Alessandro PL, Vorherr T, Johnsson K. Scarabelli S, et al. Among authors: d alessandro pl. ACS Sens. 2017 Aug 25;2(8):1191-1197. doi: 10.1021/acssensors.7b00331. Epub 2017 Aug 2. ACS Sens. 2017. PMID: 28766337
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP. D'Alessandro PL, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):759-62. doi: 10.1016/j.bmcl.2009.11.032. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20005096