Brock K - Search Results

1

Disease variant prediction with deep generative models of evolutionary data.

Frazer J, Notin P, Dias M, Gomez A, Min JK, Brock K, Gal Y, Marks DS. Frazer J, et al. Among authors: brock k. Nature. 2021 Nov;599(7883):91-95. doi: 10.1038/s41586-021-04043-8. Epub 2021 Oct 27. Nature. 2021. PMID: 34707284

2

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.

Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Sjodt M, et al. Among authors: brock k. Nature. 2018 Apr 5;556(7699):118-121. doi: 10.1038/nature25985. Epub 2018 Mar 28. Nature. 2018. PMID: 29590088 Free PMC article.

3

Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Zheng S, et al. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6709-6714. doi: 10.1073/pnas.1802192115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891673 Free PMC article.

4

The EVcouplings Python framework for coevolutionary sequence analysis.

Hopf TA, Green AG, Schubert B, Mersmann S, Schärfe CPI, Ingraham JB, Toth-Petroczy A, Brock K, Riesselman AJ, Palmedo P, Kang C, Sheridan R, Draizen EJ, Dallago C, Sander C, Marks DS. Hopf TA, et al. Among authors: brock k. Bioinformatics. 2019 May 1;35(9):1582-1584. doi: 10.1093/bioinformatics/bty862. Bioinformatics. 2019. PMID: 30304492 Free PMC article.

5

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC. Sui X, et al. J Cell Biol. 2018 Dec 3;217(12):4080-4091. doi: 10.1083/jcb.201809067. Epub 2018 Oct 16. J Cell Biol. 2018. PMID: 30327422 Free PMC article.

6

Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis.

Ramírez-Guadiana FH, Rodrigues CDA, Marquis KA, Campo N, Barajas-Ornelas RDC, Brock K, Marks DS, Kruse AC, Rudner DZ. Ramírez-Guadiana FH, et al. Among authors: brock k. PLoS Genet. 2018 Nov 7;14(11):e1007753. doi: 10.1371/journal.pgen.1007753. eCollection 2018 Nov. PLoS Genet. 2018. PMID: 30403663 Free PMC article.

7

Combining Evolutionary Covariance and NMR Data for Protein Structure Determination.

Huang YJ, Brock KP, Ishida Y, Swapna GVT, Inouye M, Marks DS, Sander C, Montelione GT. Huang YJ, et al. Methods Enzymol. 2019;614:363-392. doi: 10.1016/bs.mie.2018.11.004. Epub 2018 Dec 23. Methods Enzymol. 2019. PMID: 30611430 Free PMC article.

8

A Hybrid Approach for Protein Structure Determination Combining Sparse NMR with Evolutionary Coupling Sequence Data.

Huang YJ, Brock KP, Sander C, Marks DS, Montelione GT. Huang YJ, et al. Adv Exp Med Biol. 2018;1105:153-169. doi: 10.1007/978-981-13-2200-6_10. Adv Exp Med Biol. 2018. PMID: 30617828 Free PMC article. Review.

9

Inferring protein 3D structure from deep mutation scans.

Rollins NJ, Brock KP, Poelwijk FJ, Stiffler MA, Gauthier NP, Sander C, Marks DS. Rollins NJ, et al. Nat Genet. 2019 Jul;51(7):1170-1176. doi: 10.1038/s41588-019-0432-9. Epub 2019 Jun 17. Nat Genet. 2019. PMID: 31209393 Free PMC article.

10

Protein Structure from Experimental Evolution.

Stiffler MA, Poelwijk FJ, Brock KP, Stein RR, Riesselman A, Teyra J, Sidhu SS, Marks DS, Gauthier NP, Sander C. Stiffler MA, et al. Cell Syst. 2020 Jan 22;10(1):15-24.e5. doi: 10.1016/j.cels.2019.11.008. Epub 2019 Dec 11. Cell Syst. 2020. PMID: 31838147 Free article.

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