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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.
Saenz SA, Local A, Carr T, Shakya A, Koul S, Hu H, Chourb L, Stedman J, Malley J, D'Agostino LA, Shanmugasundaram V, Malona J, Schwartz CE, Beebe L, Clements M, Rajaraman G, Cho J, Jiang L, Dubrovskiy A, Kreilein M, Shimanovich R, Hamann LG, Escoubet L, Ellis JM. Saenz SA, et al. Among authors: dubrovskiy a. PLoS One. 2021 Nov 9;16(11):e0248034. doi: 10.1371/journal.pone.0248034. eCollection 2021. PLoS One. 2021. PMID: 34752458 Free PMC article.
Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Liu H, Niu D, Tham Sjin RT, Dubrovskiy A, Zhu Z, McDonald JJ, Fahnoe K, Wang Z, Munson M, Scholte A, Barrague M, Fitzgerald M, Liu J, Kothe M, Sun F, Murtie J, Ge J, Rocnik J, Harvey D, Ospina B, Perron K, Zheng G, Shehu E, D'Agostino LA. Liu H, et al. Among authors: dubrovskiy a. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904. doi: 10.1021/acsmedchemlett.9b00601. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062171 Free PMC article.
Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.
Evans EK, Tester R, Aslanian S, Karp R, Sheets M, Labenski MT, Witowski SR, Lounsbury H, Chaturvedi P, Mazdiyasni H, Zhu Z, Nacht M, Freed MI, Petter RC, Dubrovskiy A, Singh J, Westlin WF. Evans EK, et al. Among authors: dubrovskiy a. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. doi: 10.1124/jpet.113.203489. Epub 2013 May 24. J Pharmacol Exp Ther. 2013. PMID: 23709115 Clinical Trial.
Total Synthesis of Ritterazine B.
Nakayama Y, Maser MR, Okita T, Dubrovskiy AV, Campbell TL, Reisman SE. Nakayama Y, et al. Among authors: dubrovskiy av. J Am Chem Soc. 2021 Mar 24;143(11):4187-4192. doi: 10.1021/jacs.1c01372. Epub 2021 Mar 9. J Am Chem Soc. 2021. PMID: 33689345
28 results