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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.
PLoS One. 2021 Nov 9;16(11):e0248034. doi: 10.1371/journal.pone.0248034. eCollection 2021.
PLoS One. 2021.
PMID: 34752458
Free PMC article.
Luxeptinib (CG-806) Targets FLT3 and Clusters of Kinases Operative in Acute Myeloid Leukemia.
Rice WG, Howell SB, Zhang H, Rastgoo N, Local A, Kurtz SE, Lo P, Bottomly D, Wilmot B, McWeeney SK, Druker BJ, Tyner JW.
Rice WG, et al. Among authors: local a.
Mol Cancer Ther. 2022 Jul 5;21(7):1125-1135. doi: 10.1158/1535-7163.MCT-21-0832.
Mol Cancer Ther. 2022.
PMID: 35499387
Free PMC article.
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APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells.
Local A, Zhang H, Benbatoul KD, Folger P, Sheng X, Tsai CY, Howell SB, Rice WG.
Local A, et al.
Mol Cancer Ther. 2018 Jun;17(6):1177-1186. doi: 10.1158/1535-7163.MCT-17-1209. Epub 2018 Apr 6.
Mol Cancer Ther. 2018.
PMID: 29626127
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APTO-253 Is a New Addition to the Repertoire of Drugs that Can Exploit DNA BRCA1/2 Deficiency.
Tsai CY, Sun S, Zhang H, Local A, Su Y, Gross LA, Rice WG, Howell SB.
Tsai CY, et al. Among authors: local a.
Mol Cancer Ther. 2018 Jun;17(6):1167-1176. doi: 10.1158/1535-7163.MCT-17-0834. Epub 2018 Apr 6.
Mol Cancer Ther. 2018.
PMID: 29626126
Free PMC article.
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Identification of H3K4me1-associated proteins at mammalian enhancers.
Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B.
Local A, et al.
Nat Genet. 2018 Jan;50(1):73-82. doi: 10.1038/s41588-017-0015-6. Epub 2017 Dec 18.
Nat Genet. 2018.
PMID: 29255264
Free PMC article.
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Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers.
Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B.
Yan J, et al. Among authors: local a.
Cell Res. 2018 Feb;28(2):204-220. doi: 10.1038/cr.2018.1. Epub 2018 Jan 9.
Cell Res. 2018.
PMID: 29313530
Free PMC article.
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Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers.
Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B.
Yan J, et al. Among authors: local a.
Cell Res. 2018 Mar;28(3):387. doi: 10.1038/cr.2018.18.
Cell Res. 2018.
PMID: 29497152
Free PMC article.
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Identification and expression of cotton (Gossypium hirsutum L.) plastidial carbonic anhydrase.
Hoang CV, Wessler HG, Local A, Turley RB, Benjamin RC, Chapman KD.
Hoang CV, et al. Among authors: local a.
Plant Cell Physiol. 1999 Dec;40(12):1262-70. doi: 10.1093/oxfordjournals.pcp.a029514.
Plant Cell Physiol. 1999.
PMID: 10682348
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