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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.
Saenz SA, Local A, Carr T, Shakya A, Koul S, Hu H, Chourb L, Stedman J, Malley J, D'Agostino LA, Shanmugasundaram V, Malona J, Schwartz CE, Beebe L, Clements M, Rajaraman G, Cho J, Jiang L, Dubrovskiy A, Kreilein M, Shimanovich R, Hamann LG, Escoubet L, Ellis JM. Saenz SA, et al. Among authors: shakya a. PLoS One. 2021 Nov 9;16(11):e0248034. doi: 10.1371/journal.pone.0248034. eCollection 2021. PLoS One. 2021. PMID: 34752458 Free PMC article.
Dynamic regulatory network controlling TH17 cell differentiation.
Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Yosef N, et al. Among authors: shakya a. Nature. 2013 Apr 25;496(7446):461-8. doi: 10.1038/nature11981. Epub 2013 Mar 6. Nature. 2013. PMID: 23467089 Free PMC article.
Oct1 and OCA-B are selectively required for CD4 memory T cell function.
Shakya A, Goren A, Shalek A, German CN, Snook J, Kuchroo VK, Yosef N, Chan RC, Regev A, Williams MA, Tantin D. Shakya A, et al. J Exp Med. 2015 Nov 16;212(12):2115-31. doi: 10.1084/jem.20150363. Epub 2015 Oct 19. J Exp Med. 2015. PMID: 26481684 Free PMC article.
260 results