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Application of a high-resolution in vitro human MDR1-MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration.
Jiang L, Kumar S, Nuechterlein M, Reyes M, Tran D, Cabebe C, Chiang P, Reynolds J, Carrier S, Sun Y, Eddershaw P, Hay T, Chen W, Feng B. Jiang L, et al. Among authors: chiang p. Pharmacol Res Perspect. 2022 Feb;10(1):e00932. doi: 10.1002/prp2.932. Pharmacol Res Perspect. 2022. PMID: 35156331 Free PMC article.
Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.
Ernst JT, Neubert T, Liu M, Sperry S, Zuccola H, Turnbull A, Fleck B, Kargo W, Woody L, Chiang P, Tran D, Chen W, Snyder P, Alcacio T, Nezami A, Reynolds J, Alvi K, Goulet L, Stamos D. Ernst JT, et al. Among authors: chiang p. J Med Chem. 2014 Apr 24;57(8):3382-400. doi: 10.1021/jm500042s. Epub 2014 Apr 10. J Med Chem. 2014. PMID: 24673104
Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.
Clemens JJ, Coon T, Busch BB, Asgian JL, Hudson S, Termin A, Flores TB, Tran D, Chiang P, Sperry S, Gross R, Abt J, Heim R, Lechner S, Twin H, Studley J, Brenchley G, Collier PN, Pierard F, Miller A, Mak C, Dvornikovs V, Jimenez JM, Stamos D. Clemens JJ, et al. Among authors: chiang p. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3398-402. doi: 10.1016/j.bmcl.2014.05.082. Epub 2014 Jun 5. Bioorg Med Chem Lett. 2014. PMID: 24939756
Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization.
Chang KJ, Wu HY, Chiang PH, Hsu YT, Weng PY, Yu TH, Li CY, Chen YH, Dai HJ, Tsai HY, Chang YJ, Wu YR, Yang YP, Li CT, Hsu CC, Chen SJ, Chen YC, Cheng CY, Hsieh AR, Chiou SH. Chang KJ, et al. Among authors: chiang ph. J Adv Res. 2024 Mar 27:S2090-1232(24)00115-2. doi: 10.1016/j.jare.2024.03.015. Online ahead of print. J Adv Res. 2024. PMID: 38548265 Free article.
1,154 results