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Application of a high-resolution in vitro human MDR1-MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration.
Jiang L, Kumar S, Nuechterlein M, Reyes M, Tran D, Cabebe C, Chiang P, Reynolds J, Carrier S, Sun Y, Eddershaw P, Hay T, Chen W, Feng B. Jiang L, et al. Among authors: eddershaw p. Pharmacol Res Perspect. 2022 Feb;10(1):e00932. doi: 10.1002/prp2.932. Pharmacol Res Perspect. 2022. PMID: 35156331 Free PMC article.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Petersson C, Zhou X, Berghausen J, Cebrian D, Davies M, DeMent K, Eddershaw P, Riedmaier AE, Leblanc AF, Manveski N, Marathe P, Mavroudis PD, McDougall R, Parrott N, Reichel A, Rotter C, Tess D, Volak LP, Xiao G, Yang Z, Baker J. Petersson C, et al. Among authors: eddershaw p. AAPS J. 2022 Jul 19;24(5):85. doi: 10.1208/s12248-022-00735-9. AAPS J. 2022. PMID: 35854202 Review.
The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
Price DF, Luscombe CN, Eddershaw PJ, Edwards CD, Gumbleton M. Price DF, et al. Among authors: eddershaw pj. Pharm Res. 2017 Dec;34(12):2498-2516. doi: 10.1007/s11095-017-2220-5. Epub 2017 Jul 12. Pharm Res. 2017. PMID: 28702798 Free PMC article.
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
Lomas DA, Irving JA, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, Chung CW, Dave H, Denis A, Dodic N, Dossang A, Eddershaw P, Klimaszewska D, Haq I, Holmes DS, Hutchinson JP, Jagger AM, Jakhria T, Jigorel E, Liddle J, Lind K, Marciniak SJ, Messer J, Neu M, Olszewski A, Ordonez A, Ronzoni R, Rowedder J, Rüdiger M, Skinner S, Smith KJ, Terry R, Trottet L, Uings I, Wilson S, Zhu Z, Pearce AC. Lomas DA, et al. Among authors: eddershaw p. EMBO Mol Med. 2021 Mar 5;13(3):e13167. doi: 10.15252/emmm.202013167. Epub 2021 Jan 29. EMBO Mol Med. 2021. PMID: 33512066 Free PMC article.
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Liddle J, Pearce AC, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, Chung CW, Denis A, Dodic N, Dossang A, Eddershaw P, Klimaszewska D, Haq I, Holmes DS, Jagger A, Jakhria T, Jigorel E, Lind K, Messer J, Neu M, Olszewski A, Ronzoni R, Rowedder J, Rüdiger M, Skinner S, Smith KJ, Trottet L, Uings I, Zhu Z, Irving JA, Lomas DA. Liddle J, et al. Among authors: eddershaw p. Bioorg Med Chem Lett. 2021 Jun 1;41:127973. doi: 10.1016/j.bmcl.2021.127973. Epub 2021 Mar 19. Bioorg Med Chem Lett. 2021. PMID: 33753261
ADME SARfari: comparative genomics of drug metabolizing systems.
Davies M, Dedman N, Hersey A, Papadatos G, Hall MD, Cucurull-Sanchez L, Jeffrey P, Hasan S, Eddershaw PJ, Overington JP. Davies M, et al. Among authors: eddershaw pj. Bioinformatics. 2015 May 15;31(10):1695-7. doi: 10.1093/bioinformatics/btv010. Epub 2015 Jan 8. Bioinformatics. 2015. PMID: 25964657 Free PMC article.
34 results