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Application of a high-resolution in vitro human MDR1-MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration.
Jiang L, Kumar S, Nuechterlein M, Reyes M, Tran D, Cabebe C, Chiang P, Reynolds J, Carrier S, Sun Y, Eddershaw P, Hay T, Chen W, Feng B. Jiang L, et al. Among authors: feng b. Pharmacol Res Perspect. 2022 Feb;10(1):e00932. doi: 10.1002/prp2.932. Pharmacol Res Perspect. 2022. PMID: 35156331 Free PMC article.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.
Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Among authors: feng b. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.
Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance.
Zamek-Gliszczynski MJ, Sangha V, Shen H, Feng B, Wittwer MB, Varma MVS, Liang X, Sugiyama Y, Zhang L, Bendayan R; International Transporter Consortium. Zamek-Gliszczynski MJ, et al. Among authors: feng b. Clin Pharmacol Ther. 2022 Sep;112(3):485-500. doi: 10.1002/cpt.2644. Epub 2022 Jun 29. Clin Pharmacol Ther. 2022. PMID: 35561119 Review.
3,585 results