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Respiratory benefit in preterm lambs is progressively lost when the concentration of fetal plasma betamethasone is titrated below two nanograms per milliliter.
Fee EL, Takahashi T, Takahashi Y, Carter SWD, Clarke MW, Milad MA, Usuda H, Ikeda H, Kumagai Y, Saito Y, Ireland DJ, Newnham JP, Saito M, Jobe AH, Kemp MW. Fee EL, et al. Among authors: milad ma. Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1;325(5):L628-L637. doi: 10.1152/ajplung.00139.2023. Epub 2023 Sep 12. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37697929
Antenatal corticosteroids in Singapore: A clinical and scientific assessment.
Gosavi A, Amin Z, David Carter SW, Choolani MA, Fee EL, Milad MA, Jobe AH, Kemp MW. Gosavi A, et al. Among authors: milad ma. Singapore Med J. 2022 Oct 6. doi: 10.4103/SINGAPOREMEDJ.SMJ-2022-014. Online ahead of print. Singapore Med J. 2022. PMID: 36254928 Free article. Review.
Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen but with reduced endocrine disruption in a sheep model of pregnancy.
Usuda H, Fee EL, Carter S, Furfaro L, Takahashi T, Takahashi Y, Newnham JP, Milad MA, Saito M, Jobe AH, Kemp MW. Usuda H, et al. Among authors: milad ma. Am J Obstet Gynecol. 2022 Dec;227(6):903.e1-903.e16. doi: 10.1016/j.ajog.2022.06.058. Epub 2022 Jul 2. Am J Obstet Gynecol. 2022. PMID: 35792176 Free article.
One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus.
Fee EL, Takahashi T, Takahashi Y, Carter S, Furfaro L, Clarke MW, Milad MA, Usuda H, Newnham JP, Saito M, Jobe AH, Kemp MW. Fee EL, et al. Among authors: milad ma. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L853-L865. doi: 10.1152/ajplung.00058.2022. Epub 2022 Apr 19. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35438005 Free article.
Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy.
Takahashi T, Takahashi Y, Fee EL, Saito M, Yaegashi N, Usuda H, Bridges JP, Milad MA, Furfaro L, Carter S, Schmidt AF, Newnham JP, Jobe AH, Kemp MW. Takahashi T, et al. Among authors: milad ma. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L784-L793. doi: 10.1152/ajplung.00018.2022. Epub 2022 Apr 5. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35380907 Free article.
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