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Structure-Based Evolution of G Protein-Biased μ-Opioid Receptor Agonists.
Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK, Gmeiner P. Wang H, et al. Among authors: kaindl j. Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202200269. doi: 10.1002/anie.202200269. Epub 2022 Apr 29. Angew Chem Int Ed Engl. 2022. PMID: 35385593 Free PMC article.
Structure-guided development of heterodimer-selective GPCR ligands.
Hübner H, Schellhorn T, Gienger M, Schaab C, Kaindl J, Leeb L, Clark T, Möller D, Gmeiner P. Hübner H, et al. Among authors: kaindl j. Nat Commun. 2016 Jul 26;7:12298. doi: 10.1038/ncomms12298. Nat Commun. 2016. PMID: 27457610 Free PMC article.
Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P. Liu H, et al. Among authors: kaindl j. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7. Proc Natl Acad Sci U S A. 2018. PMID: 30404914 Free PMC article.
Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists.
Fischer O, Hofmann J, Rampp H, Kaindl J, Pratsch G, Bartuschat A, Taudte RV, Fromm MF, Hübner H, Gmeiner P, Heinrich MR. Fischer O, et al. Among authors: kaindl j. J Med Chem. 2020 Apr 23;63(8):4349-4369. doi: 10.1021/acs.jmedchem.0c00297. Epub 2020 Apr 9. J Med Chem. 2020. PMID: 32202101
28 results