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A naturally occurring single amino acid replacement in multiple gene regulator of group A Streptococcus significantly increases virulence.
Sanson M, O'Neill BE, Kachroo P, Anderson JR, Flores AR, Valson C, Cantu CC, Makthal N, Karmonik C, Fittipaldi N, Kumaraswami M, Musser JM, Olsen RJ. Sanson M, et al. Among authors: flores ar. Am J Pathol. 2015 Feb;185(2):462-71. doi: 10.1016/j.ajpath.2014.10.018. Epub 2014 Dec 2. Am J Pathol. 2015. PMID: 25476528 Free PMC article.
Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes.
Flores AR, Galloway-Peña J, Sahasrabhojane P, Saldaña M, Yao H, Su X, Ajami NJ, Holder ME, Petrosino JF, Thompson E, Margarit Y Ros I, Rosini R, Grandi G, Horstmann N, Teatero S, McGeer A, Fittipaldi N, Rappuoli R, Baker CJ, Shelburne SA. Flores AR, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):6431-6. doi: 10.1073/pnas.1504725112. Epub 2015 May 4. Proc Natl Acad Sci U S A. 2015. PMID: 25941374 Free PMC article.
127 results