Dennis EA - Search Results

1

Membrane Association Allosterically Regulates Phospholipase A₂ Enzymes and Their Specificity.

Mouchlis VD, Dennis EA. Mouchlis VD, et al. Among authors: dennis ea. Acc Chem Res. 2022 Dec 6;55(23):3303-3311. doi: 10.1021/acs.accounts.2c00497. Epub 2022 Oct 31. Acc Chem Res. 2022. PMID: 36315840 Free PMC article.

2

Phospholipase A2 biochemistry.

Burke JE, Dennis EA. Burke JE, et al. Among authors: dennis ea. Cardiovasc Drugs Ther. 2009 Feb;23(1):49-59. doi: 10.1007/s10557-008-6132-9. Epub 2008 Oct 18. Cardiovasc Drugs Ther. 2009. PMID: 18931897 Free PMC article. Review.

3

Phospholipase A2 structure/function, mechanism, and signaling.

Burke JE, Dennis EA. Burke JE, et al. Among authors: dennis ea. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S237-42. doi: 10.1194/jlr.R800033-JLR200. Epub 2008 Nov 14. J Lipid Res. 2009. PMID: 19011112 Free PMC article. Review.

4

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.

Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL Jr, McCammon JA, Dennis EA. Burke JE, et al. Among authors: dennis ea. J Am Chem Soc. 2009 Jun 17;131(23):8083-91. doi: 10.1021/ja900098y. J Am Chem Soc. 2009. PMID: 19459633 Free PMC article.

5

Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.

Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Mouchlis VD, et al. Among authors: dennis ea. J Chem Inf Model. 2012 Jan 23;52(1):243-54. doi: 10.1021/ci2005093. Epub 2012 Jan 10. J Chem Inf Model. 2012. PMID: 22196172 Free PMC article.

6

Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.

Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL Jr, McCammon JA, Dennis EA. Hsu YH, et al. Among authors: dennis ea. J Am Chem Soc. 2013 Jan 30;135(4):1330-7. doi: 10.1021/ja306490g. Epub 2013 Jan 16. J Am Chem Soc. 2013. PMID: 23256506 Free PMC article.

7

Insertion of the Ca²⁺-independent phospholipase A₂ into a phospholipid bilayer via coarse-grained and atomistic molecular dynamics simulations.

Bucher D, Hsu YH, Mouchlis VD, Dennis EA, McCammon JA. Bucher D, et al. Among authors: dennis ea. PLoS Comput Biol. 2013;9(7):e1003156. doi: 10.1371/journal.pcbi.1003156. Epub 2013 Jul 25. PLoS Comput Biol. 2013. PMID: 23935474 Free PMC article.

8

Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates.

Mouchlis VD, Bucher D, McCammon JA, Dennis EA. Mouchlis VD, et al. Among authors: dennis ea. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E516-25. doi: 10.1073/pnas.1424651112. Epub 2015 Jan 26. Proc Natl Acad Sci U S A. 2015. PMID: 25624474 Free PMC article.

9

Membrane and inhibitor interactions of intracellular phospholipases A2.

Mouchlis VD, Dennis EA. Mouchlis VD, et al. Among authors: dennis ea. Adv Biol Regul. 2016 May;61:17-24. doi: 10.1016/j.jbior.2015.11.011. Epub 2015 Dec 19. Adv Biol Regul. 2016. PMID: 26774606 Free PMC article. Review.

10

Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships.

Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Mouchlis VD, et al. Among authors: dennis ea. J Med Chem. 2016 May 12;59(9):4403-14. doi: 10.1021/acs.jmedchem.6b00377. Epub 2016 Apr 28. J Med Chem. 2016. PMID: 27087127 Free PMC article.

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