Mouchlis VD - Search Results

1

Membrane Association Allosterically Regulates Phospholipase A₂ Enzymes and Their Specificity.

Mouchlis VD, Dennis EA. Mouchlis VD, et al. Acc Chem Res. 2022 Dec 6;55(23):3303-3311. doi: 10.1021/acs.accounts.2c00497. Epub 2022 Oct 31. Acc Chem Res. 2022. PMID: 36315840 Free PMC article.

2

Membrane and inhibitor interactions of intracellular phospholipases A2.

Mouchlis VD, Dennis EA. Mouchlis VD, et al. Adv Biol Regul. 2016 May;61:17-24. doi: 10.1016/j.jbior.2015.11.011. Epub 2015 Dec 19. Adv Biol Regul. 2016. PMID: 26774606 Free PMC article. Review.

3

Review of four major distinct types of human phospholipase A₂.

Vasquez AM, Mouchlis VD, Dennis EA. Vasquez AM, et al. Among authors: mouchlis vd. Adv Biol Regul. 2018 Jan;67:212-218. doi: 10.1016/j.jbior.2017.10.009. Epub 2017 Oct 23. Adv Biol Regul. 2018. PMID: 29248300 Free PMC article. Review.

4

Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity.

Mouchlis VD, Chen Y, McCammon JA, Dennis EA. Mouchlis VD, et al. J Am Chem Soc. 2018 Mar 7;140(9):3285-3291. doi: 10.1021/jacs.7b12045. Epub 2018 Feb 26. J Am Chem Soc. 2018. PMID: 29342349 Free PMC article.

5

Substrate-Specific Inhibition Constants for Phospholipase A₂ Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics.

Mouchlis VD, Armando A, Dennis EA. Mouchlis VD, et al. J Med Chem. 2019 Feb 28;62(4):1999-2007. doi: 10.1021/acs.jmedchem.8b01568. Epub 2019 Feb 4. J Med Chem. 2019. PMID: 30615445 Free PMC article.

6

Phospholipase A₂ catalysis and lipid mediator lipidomics.

Mouchlis VD, Dennis EA. Mouchlis VD, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):766-771. doi: 10.1016/j.bbalip.2018.08.010. Epub 2018 Aug 23. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 30905345 Free PMC article. Review.

7

Each phospholipase A₂ type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids.

Hayashi D, Mouchlis VD, Dennis EA. Hayashi D, et al. Among authors: mouchlis vd. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159067. doi: 10.1016/j.bbalip.2021.159067. Epub 2021 Oct 9. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34634490 Free PMC article.

8

Lipoprotein-associated phospholipase A₂: A paradigm for allosteric regulation by membranes.

Mouchlis VD, Hayashi D, Vasquez AM, Cao J, McCammon JA, Dennis EA. Mouchlis VD, et al. Proc Natl Acad Sci U S A. 2022 Jan 11;119(2):e2102953118. doi: 10.1073/pnas.2102953118. Proc Natl Acad Sci U S A. 2022. PMID: 34996868 Free PMC article.

9

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A₂ inhibitors.

Mouchlis VD, Mu C, Hammons R, Dennis EA. Mouchlis VD, et al. Adv Biol Regul. 2020 May;76:100719. doi: 10.1016/j.jbior.2020.100719. Epub 2020 Mar 10. Adv Biol Regul. 2020. PMID: 32199750 Free PMC article.

10

Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics.

Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Mouchlis VD, et al. J Chem Inf Model. 2012 Jan 23;52(1):243-54. doi: 10.1021/ci2005093. Epub 2012 Jan 10. J Chem Inf Model. 2012. PMID: 22196172 Free PMC article.

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