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Single-cell spatial immune landscapes of primary and metastatic brain tumours.
Karimi E, Yu MW, Maritan SM, Perus LJM, Rezanejad M, Sorin M, Dankner M, Fallah P, Doré S, Zuo D, Fiset B, Kloosterman DJ, Ramsay L, Wei Y, Lam S, Alsajjan R, Watson IR, Roldan Urgoiti G, Park M, Brandsma D, Senger DL, Chan JA, Akkari L, Petrecca K, Guiot MC, Siegel PM, Quail DF, Walsh LA. Karimi E, et al. Among authors: kloosterman dj. Nature. 2023 Feb;614(7948):555-563. doi: 10.1038/s41586-022-05680-3. Epub 2023 Feb 1. Nature. 2023. PMID: 36725935 Free PMC article.
Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells.
Couturier CP, Nadaf J, Li Z, Baig S, Riva G, Le P, Kloosterman DJ, Monlong J, Nkili Meyong A, Allache R, Degenhard T, Al-Rashid M, Guiot MC, Bourque G, Ragoussis J, Akkari L, Quintana FJ, Petrecca K. Couturier CP, et al. Among authors: kloosterman dj. Neuro Oncol. 2022 Sep 1;24(9):1494-1508. doi: 10.1093/neuonc/noac085. Neuro Oncol. 2022. PMID: 35416251 Free PMC article.
CD103+ regulatory T cells underlie resistance to radio-immunotherapy and impair CD8+ T cell activation in glioblastoma.
van Hooren L, Handgraaf SM, Kloosterman DJ, Karimi E, van Mil LWHG, Gassama AA, Solsona BG, de Groot MHP, Brandsma D, Quail DF, Walsh LA, Borst GR, Akkari L. van Hooren L, et al. Among authors: kloosterman dj. Nat Cancer. 2023 May;4(5):665-681. doi: 10.1038/s43018-023-00547-6. Epub 2023 Apr 20. Nat Cancer. 2023. PMID: 37081259 Free PMC article.
Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma.
Ramirez CFA, Taranto D, Ando-Kuri M, de Groot MHP, Tsouri E, Huang Z, de Groot D, Kluin RJC, Kloosterman DJ, Verheij J, Xu J, Vegna S, Akkari L. Ramirez CFA, et al. Among authors: kloosterman dj. Nat Commun. 2024 Mar 22;15(1):2581. doi: 10.1038/s41467-024-46835-2. Nat Commun. 2024. PMID: 38519484 Free PMC article.