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Combinatorial inhibition of Tec kinases BTK and ITK is beneficial in ameliorating murine sclerodermatous chronic graft versus host disease.
Palaniyandi S, Strattan E, Kumari R, Mysinger M, Hakim N, Kesler MV, Apatira M, Bittencourt F, Wang L, Jia Z, Gururaja TL, Hill RJ, Hildebrandt GC. Palaniyandi S, et al. Among authors: gururaja tl. Bone Marrow Transplant. 2023 Aug;58(8):924-935. doi: 10.1038/s41409-023-02001-8. Epub 2023 May 9. Bone Marrow Transplant. 2023. PMID: 37160943
Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.
McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. Among authors: gururaja tl. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559
R-253 disrupts microtubule networks in multiple tumor cell lines.
Gururaja TL, Goff D, Kinoshita T, Goldstein E, Yung S, McLaughlin J, Pali E, Huang J, Singh R, Daniel-Issakani S, Hitoshi Y, Cooper RD, Payan DG. Gururaja TL, et al. Clin Cancer Res. 2006 Jun 15;12(12):3831-42. doi: 10.1158/1078-0432.CCR-06-0168. Clin Cancer Res. 2006. PMID: 16778111
21 results