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RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells.
Chen F, Gurler SB, Novo D, Selli C, Alferez DG, Eroglu S, Pavlou K, Zhang J, Sims AH, Humphreys NE, Adamson A, Campbell A, Sansom OJ, Tournier C, Clarke RB, Brennan K, Streuli CH, Ucar A. Chen F, et al. Among authors: humphreys ne. Oncogene. 2023 Feb;42(9):679-692. doi: 10.1038/s41388-022-02574-6. Epub 2023 Jan 5. Oncogene. 2023. PMID: 36599922 Free PMC article.
A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS. Talbot F, et al. Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3. Nat Commun. 2023. PMID: 36922513 Free PMC article.
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing.
Chuntharpursat-Bon E, Povstyan OV, Ludlow MJ, Carrier DJ, Debant M, Shi J, Gaunt HJ, Bauer CC, Curd A, Simon Futers T, Baxter PD, Peckham M, Muench SP, Adamson A, Humphreys N, Tumova S, Bon RS, Cubbon R, Lichtenstein L, Beech DJ. Chuntharpursat-Bon E, et al. Commun Biol. 2023 Apr 1;6(1):358. doi: 10.1038/s42003-023-04706-4. Commun Biol. 2023. PMID: 37005489 Free PMC article.
A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling.
Stables J, Green EK, Sehgal A, Patkar OL, Keshvari S, Taylor I, Ashcroft ME, Grabert K, Wollscheid-Lengeling E, Szymkowiak S, McColl BW, Adamson A, Humphreys NE, Mueller W, Starobova H, Vetter I, Shabestari SK, Blurton-Jones MM, Summers KM, Irvine KM, Pridans C, Hume DA. Stables J, et al. Among authors: humphreys ne. Development. 2022 Apr 15;149(8):dev200237. doi: 10.1242/dev.200237. Epub 2022 Mar 25. Development. 2022. PMID: 35333324 Free PMC article.
A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.
Grabert K, Sehgal A, Irvine KM, Wollscheid-Lengeling E, Ozdemir DD, Stables J, Luke GA, Ryan MD, Adamson A, Humphreys NE, Sandrock CJ, Rojo R, Verkasalo VA, Mueller W, Hohenstein P, Pettit AR, Pridans C, Hume DA. Grabert K, et al. Among authors: humphreys ne. J Immunol. 2020 Dec 1;205(11):3154-3166. doi: 10.4049/jimmunol.2000835. Epub 2020 Nov 2. J Immunol. 2020. PMID: 33139489
Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease.
Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W, Waisman A. Pinteaux E, et al. Among authors: humphreys ne. J Mol Med (Berl). 2020 Jul;98(7):923-930. doi: 10.1007/s00109-020-01928-5. Epub 2020 May 29. J Mol Med (Berl). 2020. PMID: 32468079 Free PMC article. Review.
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D. Baxter M, et al. Among authors: humphreys ne. Elife. 2020 Jan 15;9:e50705. doi: 10.7554/eLife.50705. Elife. 2020. PMID: 31939735 Free PMC article.
29 results