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Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Mowery CT, Freimer JW, Chen Z, Casaní-Galdón S, Umhoefer JM, Arce MM, Gjoni K, Daniel B, Sandor K, Gowen BG, Nguyen V, Simeonov DR, Garrido CM, Curie GL, Schmidt R, Steinhart Z, Satpathy AT, Pollard KS, Corn JE, Bernstein BE, Ye CJ, Marson A. Mowery CT, et al. Among authors: corn je. Nat Genet. 2024 May 29. doi: 10.1038/s41588-024-01743-5. Online ahead of print. Nat Genet. 2024. PMID: 38811842
Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.
Rajendiran V, Devaraju N, Haddad M, Ravi NS, Panigrahi L, Paul J, Gopalakrishnan C, Wyman S, Ariudainambi K, Mahalingam G, Periyasami Y, Prasad K, George A, Sukumaran D, Gopinathan S, Pai AA, Nakamura Y, Balasubramanian P, Ramalingam R, Thangavel S, Velayudhan SR, Corn JE, Mackay JP, Marepally S, Srivastava A, Crossley M, Mohankumar KM. Rajendiran V, et al. Among authors: corn je. Mol Ther. 2024 Mar 6;32(3):663-677. doi: 10.1016/j.ymthe.2024.01.023. Epub 2024 Jan 24. Mol Ther. 2024. PMID: 38273654 Free article.
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy.
Marone R, Landmann E, Devaux A, Lepore R, Seyres D, Zuin J, Burgold T, Engdahl C, Capoferri G, Dell'Aglio A, Larrue C, Simonetta F, Rositzka J, Rhiel M, Andrieux G, Gallagher DN, Schröder MS, Wiederkehr A, Sinopoli A, Do Sacramento V, Haydn A, Garcia-Prat L, Divsalar C, Camus A, Xu L, Bordoli L, Schwede T, Porteus M, Tamburini J, Corn JE, Cathomen T, Cornu TI, Urlinger S, Jeker LT. Marone R, et al. Among authors: corn je. J Exp Med. 2023 Dec 4;220(12):e20231235. doi: 10.1084/jem.20231235. Epub 2023 Sep 29. J Exp Med. 2023. PMID: 37773046 Free PMC article.
Engineering of the endogenous HBD promoter increases HbA2.
Boontanrart MY, Mächler E, Ponta S, Nelis JC, Preiano VG, Corn JE. Boontanrart MY, et al. Among authors: corn je. Elife. 2023 Jun 2;12:e85258. doi: 10.7554/eLife.85258. Elife. 2023. PMID: 37265399 Free PMC article.
Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions.
Buehler M, Yi X, Ge W, Blattmann P, Rushing E, Reifenberger G, Felsberg J, Yeh C, Corn JE, Regli L, Zhang J, Cloos A, Ravi VM, Wiestler B, Heiland DH, Aebersold R, Weller M, Guo T, Weiss T. Buehler M, et al. Among authors: corn je. Neuro Oncol. 2023 Feb 14;25(2):290-302. doi: 10.1093/neuonc/noac169. Neuro Oncol. 2023. PMID: 35802605 Free PMC article.
High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation.
Magis W, DeWitt MA, Wyman SK, Vu JT, Heo SJ, Shao SJ, Hennig F, Romero ZG, Campo-Fernandez B, Said S, McNeill MS, Rettig GR, Sun Y, Wang Y, Behlke MA, Kohn DB, Boffelli D, Walters MC, Corn JE, Martin DIK. Magis W, et al. Among authors: corn je. iScience. 2022 May 10;25(6):104374. doi: 10.1016/j.isci.2022.104374. eCollection 2022 Jun 17. iScience. 2022. PMID: 35633935 Free PMC article.
85 results