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Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells.
Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Zaragoza-Huesca D, Ortega-Sabater C, Peña-García J, Espín S, Ricote G, Montenegro S, Ayala-De La Peña F, Luengo-Gil G, Nieto A, García-Molina F, Vicente V, Bernardi F, Lozano ML, Mulero V, Pérez-Sánchez H, Carmona-Bayonas A, Martínez-Martínez I. Rodenas MC, et al. Among authors: pardo sanchez i. Front Mol Biosci. 2023 May 19;10:1182925. doi: 10.3389/fmolb.2023.1182925. eCollection 2023. Front Mol Biosci. 2023. PMID: 37275957 Free PMC article.
Dual Role of DUOX1-Derived Reactive Oxygen Species in Melanoma.
Pardo-Sánchez I, Ibañez-Molero S, García-Moreno D, Mulero V. Pardo-Sánchez I, et al. Antioxidants (Basel). 2023 Mar 13;12(3):708. doi: 10.3390/antiox12030708. Antioxidants (Basel). 2023. PMID: 36978957 Free PMC article.
The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
Martínez-Navarro FJ, Martínez-Morcillo FJ, López-Muñoz A, Pardo-Sánchez I, Martínez-Menchón T, Corbalán-Vélez R, Cayuela ML, Pérez-Oliva AB, García-Moreno D, Mulero V. Martínez-Navarro FJ, et al. Among authors: pardo sanchez i. Dev Comp Immunol. 2020 Jul;108:103666. doi: 10.1016/j.dci.2020.103666. Epub 2020 Feb 29. Dev Comp Immunol. 2020. PMID: 32126244
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Tyrkalska SD, Pérez-Oliva AB, Rodríguez-Ruiz L, Martínez-Morcillo FJ, Alcaraz-Pérez F, Martínez-Navarro FJ, Lachaud C, Ahmed N, Schroeder T, Pardo-Sánchez I, Candel S, López-Muñoz A, Choudhuri A, Rossmann MP, Zon LI, Cayuela ML, García-Moreno D, Mulero V. Tyrkalska SD, et al. Among authors: pardo sanchez i. Immunity. 2019 Jul 16;51(1):50-63.e5. doi: 10.1016/j.immuni.2019.05.005. Epub 2019 Jun 4. Immunity. 2019. PMID: 31174991 Free PMC article.
Suramin, a drug for the treatment of trypanosomiasis, reduces the prothrombotic and metastatic phenotypes of colorectal cancer cells by inhibiting hepsin.
Zaragoza-Huesca D, Rodenas MC, Peñas-Martínez J, Pardo-Sánchez I, Peña-García J, Espín S, Ricote G, Nieto A, García-Molina F, Vicente V, Lozano ML, Carmona-Bayonas A, Mulero V, Pérez-Sánchez H, Martínez-Martínez I. Zaragoza-Huesca D, et al. Among authors: pardo sanchez i. Biomed Pharmacother. 2023 Dec;168:115814. doi: 10.1016/j.biopha.2023.115814. Epub 2023 Oct 31. Biomed Pharmacother. 2023. PMID: 37918256 Free article.