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Inhibition of RAS function through targeting an allosteric regulatory site.
Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Spencer-Smith R, et al. Among authors: okur mn. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820802 Free PMC article.
Proliferation defects and genome instability in cells lacking Cul4A.
Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, Raychaudhuri P. Kopanja D, et al. Among authors: okur mn. Oncogene. 2009 Jul 2;28(26):2456-65. doi: 10.1038/onc.2009.86. Epub 2009 May 11. Oncogene. 2009. PMID: 19430492 Free PMC article.
Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T. Sudhahar V, et al. Among authors: okur mn. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):529-541. doi: 10.1161/ATVBAHA.117.309819. Epub 2018 Jan 4. Arterioscler Thromb Vasc Biol. 2018. PMID: 29301787 Free PMC article.
21 results