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Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo-Controlled Study.
Kardassis D, Egnell AC, Åstrand M, Daniels SJ, Whatling C, Fjellström O, Gabrielsen A. Kardassis D, et al. Among authors: whatling c. J Am Heart Assoc. 2024 May 28:e033985. doi: 10.1161/JAHA.123.033985. Online ahead of print. J Am Heart Assoc. 2024. PMID: 38804212 Free article.
Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
Lund LH, Lam CSP, Pizzato PE, Gabrielsen A, Michaëlsson E, Nelander K, Ericsson H, Holden J, Folkvaljon F, Mattsson A, Collén A, Aurell M, Whatling C, Baldus S, Drelich G, Goudev A, Merkely B, Bergh N, Shah SJ. Lund LH, et al. Among authors: whatling c. Eur J Heart Fail. 2023 Sep;25(9):1696-1707. doi: 10.1002/ejhf.2977. Epub 2023 Aug 22. Eur J Heart Fail. 2023. PMID: 37470101 Clinical Trial.
A mechanistic framework for cardiometabolic and coronary artery diseases.
Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franzén O, Mocci G, Meelu OA, Ishikawa K, Whatling C, Jain A, Jain RK, Gan LM, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Björkegren JLM. Koplev S, et al. Among authors: whatling c. Nat Cardiovasc Res. 2022 Jan;1(1):85-100. doi: 10.1038/s44161-021-00009-1. Epub 2022 Jan 12. Nat Cardiovasc Res. 2022. PMID: 36276926 Free PMC article.
Recombinant Apyrase (AZD3366) Against Myocardial Reperfusion Injury.
Birnbaum Y, Ye R, Chen H, Carlsson L, Whatling C, Fjellström O, Ryberg E, Ye Y. Birnbaum Y, et al. Among authors: whatling c. Cardiovasc Drugs Ther. 2023 Aug;37(4):625-646. doi: 10.1007/s10557-022-07329-9. Epub 2022 Feb 22. Cardiovasc Drugs Ther. 2023. PMID: 35192075
Association of genetic variations with NAFLD in lean individuals.
Lin H, Wong GL, Whatling C, Chan AW, Leung HH, Tse CH, Shu SS, Chim AM, Lai JC, Yip TC, Wong VW. Lin H, et al. Among authors: whatling c. Liver Int. 2022 Jan;42(1):149-160. doi: 10.1111/liv.15078. Epub 2021 Oct 12. Liver Int. 2022. PMID: 34610207
Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.
Knöchel J, Nelander K, Heijer M, Lindstedt EL, Forsberg GB, Whatling C, Shimada H, Han DS, Gabrielsen A, Garkaviy P, Ericsson H. Knöchel J, et al. Among authors: whatling c. Clin Drug Investig. 2021 Oct;41(10):895-905. doi: 10.1007/s40261-021-01078-7. Epub 2021 Sep 21. Clin Drug Investig. 2021. PMID: 34546534 Free PMC article. Clinical Trial.
Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
Haemmig S, Hashemi Gheinani A, Zaromytidou M, Siasos G, Coskun AU, Cormier MA, Gross DA, Wara AKMK, Antoniadis AP, Sun X, Sukhova GK, Welt FGP, Andreou I, Whatling C, Gan LM, Wikström J, Edelman ER, Libby P, Stone PH, Feinberg MW. Haemmig S, et al. Among authors: whatling c. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1487-1503. doi: 10.1161/ATVBAHA.121.315896. Epub 2021 Feb 11. Arterioscler Thromb Vasc Biol. 2021. PMID: 33567868 Free PMC article.
An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease.
Cohain AT, Barrington WT, Jordan DM, Beckmann ND, Argmann CA, Houten SM, Charney AW, Ermel R, Sukhavasi K, Franzen O, Koplev S, Whatling C, Belbin GM, Yang J, Hao K, Kenny EE, Tu Z, Zhu J, Gan LM, Do R, Giannarelli C, Kovacic JC, Ruusalepp A, Lusis AJ, Bjorkegren JLM, Schadt EE. Cohain AT, et al. Among authors: whatling c. Nat Commun. 2021 Jan 22;12(1):547. doi: 10.1038/s41467-020-20750-8. Nat Commun. 2021. PMID: 33483510 Free PMC article.
45 results