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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Paradiso F, Sugimoto H, Arian KA, Ying H, Barekatain Y, Sthanam LK, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. Among authors: guerrero pa. Cancer Cell. 2023 Sep 11;41(9):1606-1620.e8. doi: 10.1016/j.ccell.2023.07.002. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625401
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Bernard V, Semaan A, Huang J, San Lucas FA, Mulu FC, Stephens BM, Guerrero PA, Huang Y, Zhao J, Kamyabi N, Sen S, Scheet PA, Taniguchi CM, Kim MP, Tzeng CW, Katz MH, Singhi AD, Maitra A, Alvarez HA. Bernard V, et al. Among authors: guerrero pa. Clin Cancer Res. 2019 Apr 1;25(7):2194-2205. doi: 10.1158/1078-0432.CCR-18-1955. Epub 2018 Nov 1. Clin Cancer Res. 2019. PMID: 30385653 Free PMC article.
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Bhagat TD, Von Ahrens D, Dawlaty M, Zou Y, Baddour J, Achreja A, Zhao H, Yang L, Patel B, Kwak C, Choudhary GS, Gordon-Mitchell S, Aluri S, Bhattacharyya S, Sahu S, Bhagat P, Yu Y, Bartenstein M, Giricz O, Suzuki M, Sohal D, Gupta S, Guerrero PA, Batra S, Goggins M, Steidl U, Greally J, Agarwal B, Pradhan K, Banerjee D, Nagrath D, Maitra A, Verma A. Bhagat TD, et al. Among authors: guerrero pa. Elife. 2019 Nov 1;8:e50663. doi: 10.7554/eLife.50663. Elife. 2019. PMID: 31663852 Free PMC article.
Defining the Comprehensive Genomic Landscapes of Pancreatic Ductal Adenocarcinoma Using Real-World Endoscopic Aspiration Samples.
Semaan A, Bernard V, Lee JJ, Wong JW, Huang J, Swartzlander DB, Stephens BM, Monberg ME, Weston BR, Bhutani MS, Chang K, Scheet PA, Maitra A, Jakubek YA, Guerrero PA. Semaan A, et al. Among authors: guerrero pa. Clin Cancer Res. 2021 Feb 15;27(4):1082-1093. doi: 10.1158/1078-0432.CCR-20-2667. Epub 2020 Nov 13. Clin Cancer Res. 2021. PMID: 33188144 Free PMC article.
Characterisation of circulating tumour cell phenotypes identifies a partial-EMT sub-population for clinical stratification of pancreatic cancer.
Semaan A, Bernard V, Kim DU, Lee JJ, Huang J, Kamyabi N, Stephens BM, Qiao W, Varadhachary GR, Katz MH, Shen Y, San Lucas FA, Gascoyne P, Alvarez HA, Maitra A, Guerrero PA. Semaan A, et al. Among authors: guerrero pa. Br J Cancer. 2021 Jun;124(12):1970-1977. doi: 10.1038/s41416-021-01350-9. Epub 2021 Mar 30. Br J Cancer. 2021. PMID: 33785875 Free PMC article.
Elucidation of Tumor-Stromal Heterogeneity and the Ligand-Receptor Interactome by Single-Cell Transcriptomics in Real-world Pancreatic Cancer Biopsies.
Lee JJ, Bernard V, Semaan A, Monberg ME, Huang J, Stephens BM, Lin D, Rajapakshe KI, Weston BR, Bhutani MS, Haymaker CL, Bernatchez C, Taniguchi CM, Maitra A, Guerrero PA. Lee JJ, et al. Among authors: guerrero pa. Clin Cancer Res. 2021 Nov 1;27(21):5912-5921. doi: 10.1158/1078-0432.CCR-20-3925. Epub 2021 Aug 23. Clin Cancer Res. 2021. PMID: 34426439 Free PMC article.
Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
Hosein AN, Dangol G, Okumura T, Roszik J, Rajapakshe K, Siemann M, Zaid M, Ghosh B, Monberg M, Guerrero PA, Singhi A, Haymaker CL, Clevers H, Abou-Elkacem L, Woermann SM, Maitra A. Hosein AN, et al. Among authors: guerrero pa. Gastroenterology. 2022 Apr;162(4):1303-1318.e18. doi: 10.1053/j.gastro.2021.12.273. Epub 2021 Dec 30. Gastroenterology. 2022. PMID: 34973294 Free PMC article.
Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.
Monberg ME, Geiger H, Lee JJ, Sharma R, Semaan A, Bernard V, Wong J, Wang F, Liang S, Swartzlander DB, Stephens BM, Katz MHG, Chen K, Robine N, Guerrero PA, Maitra A. Monberg ME, et al. Among authors: guerrero pa. Nat Commun. 2022 Jun 25;13(1):3652. doi: 10.1038/s41467-022-31376-3. Nat Commun. 2022. PMID: 35752636 Free PMC article.
Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner.
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Sugimoto H, Arian KA, Ying H, Barekatain Y, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Mahadevan KK, et al. Among authors: guerrero pa. bioRxiv [Preprint]. 2023 Feb 18:2023.02.15.528757. doi: 10.1101/2023.02.15.528757. bioRxiv. 2023. PMID: 36824971 Free PMC article. Preprint.
39 results