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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.
Kohlmeyer JL, Lingo JJ, Kaemmer CA, Scherer A, Warrier A, Voigt E, Raygoza Garay JA, McGivney GR, Brockman QR, Tang A, Calizo A, Pollard K, Zhang X, Hirbe AC, Pratilas CA, Leidinger M, Breheny P, Chimenti MS, Sieren JC, Monga V, Tanas MR, Meyerholz DK, Darbro BW, Dodd RD, Quelle DE. Kohlmeyer JL, et al. Among authors: quelle de. Clin Cancer Res. 2023 Sep 1;29(17):3484-3497. doi: 10.1158/1078-0432.CCR-23-0749. Clin Cancer Res. 2023. PMID: 37410426 Free PMC article.
Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo.
Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Kohlmeyer JL, et al. Among authors: quelle de. Neurooncol Adv. 2022 Apr 9;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec. Neurooncol Adv. 2022. PMID: 35571990 Free PMC article.
RABL6A Regulates Schwann Cell Senescence in an RB1-Dependent Manner.
Kohlmeyer JL, Kaemmer CA, Umesalma S, Gourronc FA, Klingelhutz AJ, Quelle DE. Kohlmeyer JL, et al. Among authors: quelle de. Int J Mol Sci. 2021 May 20;22(10):5367. doi: 10.3390/ijms22105367. Int J Mol Sci. 2021. PMID: 34065204 Free PMC article.
RABL6A Is an Essential Driver of MPNSTs that Negatively Regulates the RB1 Pathway and Sensitizes Tumor Cells to CDK4/6 Inhibitors.
Kohlmeyer JL, Kaemmer CA, Pulliam C, Maharjan CK, Samayoa AM, Major HJ, Cornick KE, Knepper-Adrian V, Khanna R, Sieren JC, Leidinger MR, Meyerholz DK, Zamba KD, Weimer JM, Dodd RD, Darbro BW, Tanas MR, Quelle DE. Kohlmeyer JL, et al. Among authors: quelle de. Clin Cancer Res. 2020 Jun 15;26(12):2997-3011. doi: 10.1158/1078-0432.CCR-19-2706. Epub 2020 Feb 21. Clin Cancer Res. 2020. PMID: 32086342 Free PMC article.
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function.
Korgaonkar C, Hagen J, Tompkins V, Frazier AA, Allamargot C, Quelle FW, Quelle DE. Korgaonkar C, et al. Among authors: quelle fw, quelle de. Mol Cell Biol. 2005 Feb;25(4):1258-71. doi: 10.1128/MCB.25.4.1258-1271.2005. Mol Cell Biol. 2005. PMID: 15684379 Free PMC article.
Combination therapies for MPNSTs targeting RABL6A-RB1 signaling.
Kohlmeyer JL, Gordon DJ, Tanas MR, Dodd RD, Monga V, Darbro BW, Quelle DE. Kohlmeyer JL, et al. Among authors: quelle de. Oncotarget. 2021 Jan 5;12(1):10-14. doi: 10.18632/oncotarget.27862. eCollection 2021 Jan 5. Oncotarget. 2021. PMID: 33456709 Free PMC article.
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