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A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke.
Lyden PD, Diniz MA, Bosetti F, Lamb J, Nagarkatti KA, Rogatko A, Kim S, Cabeen RP, Koenig JI, Akhter K, Arbab AS, Avery BD, Beatty HE, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman AL, Hyder F, Imai T, Johnson CW, Khan MB, Kamat P, Karuppagounder SS, Kumskova M, Mihailovic JM, Mandeville JB, Morais A, Patel RB, Sanganahalli BG, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez SE, Aronowski J, Ayata C, Chauhan AK, Leira EC, Hess DC, Koehler RC, McCullough LD, Sansing LH. Lyden PD, et al. Among authors: karuppagounder ss. Sci Transl Med. 2023 Sep 20;15(714):eadg8656. doi: 10.1126/scitranslmed.adg8656. Epub 2023 Sep 20. Sci Transl Med. 2023. PMID: 37729432 Clinical Trial.
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.
Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, Yan W, Li YS, Kuo SH, Redding-Ochoa J, Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS. Seo BA, et al. Among authors: karuppagounder ss. Neuron. 2021 Dec 1;109(23):3758-3774.e11. doi: 10.1016/j.neuron.2021.09.031. Epub 2021 Oct 12. Neuron. 2021. PMID: 34644545 Free PMC article.
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. Kam TI, et al. Among authors: karuppagounder ss. Science. 2018 Nov 2;362(6414):eaat8407. doi: 10.1126/science.aat8407. Science. 2018. PMID: 30385548 Free PMC article.
c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.
Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS. Brahmachari S, et al. Among authors: karuppagounder ss. J Parkinsons Dis. 2017;7(4):589-601. doi: 10.3233/JPD-171191. J Parkinsons Dis. 2017. PMID: 29103051 Free PMC article.
Versatile effects of sildenafil: recent pharmacological applications.
Uthayathas S, Karuppagounder SS, Thrash BM, Parameshwaran K, Suppiramaniam V, Dhanasekaran M. Uthayathas S, et al. Among authors: karuppagounder ss. Pharmacol Rep. 2007 Mar-Apr;59(2):150-63. Pharmacol Rep. 2007. PMID: 17556793 Free article. Review.
Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus.
Parameshwaran K, Buabeid MA, Karuppagounder SS, Uthayathas S, Thiruchelvam K, Shonesy B, Dityatev A, Escobar MC, Dhanasekaran M, Suppiramaniam V. Parameshwaran K, et al. Among authors: karuppagounder ss. Cell Mol Life Sci. 2012 Mar;69(5):829-41. doi: 10.1007/s00018-011-0805-4. Epub 2011 Oct 28. Cell Mol Life Sci. 2012. PMID: 22033836 Free PMC article.
Investigate the chronic neurotoxic effects of diquat.
Karuppagounder SS, Ahuja M, Buabeid M, Parameshwaran K, Abdel-Rehman E, Suppiramaniam V, Dhanasekaran M. Karuppagounder SS, et al. Neurochem Res. 2012 May;37(5):1102-11. doi: 10.1007/s11064-012-0715-3. Epub 2012 Feb 14. Neurochem Res. 2012. PMID: 22331545
Elucidating the neurotoxic effects of MDMA and its analogs.
Karuppagounder SS, Bhattacharya D, Ahuja M, Suppiramaniam V, Deruiter J, Clark R, Dhanasekaran M. Karuppagounder SS, et al. Life Sci. 2014 Apr 17;101(1-2):37-42. doi: 10.1016/j.lfs.2014.02.010. Epub 2014 Feb 19. Life Sci. 2014. PMID: 24560859
Effect of dopaminergic neurotoxin MPTP/MPP+ on coenzyme Q content.
Dhanasekaran M, Karuppagounder SS, Uthayathas S, Wold LE, Parameshwaran K, Jayachandra Babu R, Suppiramaniam V, Brown-Borg H. Dhanasekaran M, et al. Among authors: karuppagounder ss. Life Sci. 2008 Jul 18;83(3-4):92-5. doi: 10.1016/j.lfs.2008.04.016. Epub 2008 May 6. Life Sci. 2008. PMID: 18565546
92 results