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First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors.
Yarchoan M, Powderly JD, Bastos BR, Karasic TB, Crysler OV, Munster PN, McKean MA, Emens LA, Saenger YM, Ged Y, Stagg R, Smith S, Whiting CC, Moon A, Prasit P, Jenkins Y, Standifer N, Dubensky TW, Whiting SH, Ulahannan SV. Yarchoan M, et al. Among authors: saenger ym. Cancer Res Commun. 2024 Apr 18;4(4):1100-1110. doi: 10.1158/2767-9764.CRC-24-0082. Cancer Res Commun. 2024. PMID: 38551394 Free PMC article. Clinical Trial.
Evaluating the efficacy of combination and single-agent immunotherapies in real-world patterns of disease progression and survival of metastatic melanoma patients.
Ko B, Tao K, Brennan L, Rakhade S, Chan CX, Moone JY, Zhu R, Sher A, Wang S, Bracero Y, Fullerton B, McLellan B, Geskin LJ, Saenger YM. Ko B, et al. Among authors: saenger ym. Melanoma Res. 2024 Apr 1;34(2):134-141. doi: 10.1097/CMR.0000000000000945. Epub 2024 Jan 4. Melanoma Res. 2024. PMID: 38181115 Free PMC article.
Combining immunotherapy with high-dose radiation therapy (HDRT) significantly inhibits tumor growth in a syngeneic mouse model of high-risk neuroblastoma.
Boboila S, Okochi S, Banerjee D, Barton S, Street C, Zenilman AL, Wang Q, Gartrell RD, Saenger YM, Welch D, Wu CC, Kadenhe-Chiweshe A, Yamashiro DJ, Connolly EP. Boboila S, et al. Among authors: saenger ym. Heliyon. 2023 Jun 19;9(6):e17399. doi: 10.1016/j.heliyon.2023.e17399. eCollection 2023 Jun. Heliyon. 2023. PMID: 37408891 Free PMC article.
InterMEL: An international biorepository and clinical database to uncover predictors of survival in early-stage melanoma.
Orlow I, Sadeghi KD, Edmiston SN, Kenney JM, Lezcano C, Wilmott JS, Cust AE, Scolyer RA, Mann GJ, Lee TK, Burke H, Jakrot V, Shang P, Ferguson PM, Boyce TW, Ko JS, Ngo P, Funchain P, Rees JR, O'Connell K, Hao H, Parrish E, Conway K, Googe PB, Ollila DW, Moschos SJ, Hernando E, Hanniford D, Argibay D, Amos CI, Lee JE, Osman I, Luo L, Kuan PF, Aurora A, Gould Rothberg BE, Bosenberg MW, Gerstenblith MR, Thompson C, Bogner PN, Gorlov IP, Holmen SL, Brunsgaard EK, Saenger YM, Shen R, Seshan V, Nagore E, Ernstoff MS, Busam KJ, Begg CB, Thomas NE, Berwick M; InterMEL Consortium. Orlow I, et al. Among authors: saenger ym. PLoS One. 2023 Apr 3;18(4):e0269324. doi: 10.1371/journal.pone.0269324. eCollection 2023. PLoS One. 2023. PMID: 37011054 Free PMC article.
Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma.
Gartrell RD, Enzler T, Kim PS, Fullerton BT, Fazlollahi L, Chen AX, Minns HE, Perni S, Weisberg SP, Rizk EM, Wang S, Oh EJ, Guo XV, Chiuzan C, Manji GA, Bates SE, Chabot J, Schrope B, Kluger M, Emond J, Rabadán R, Farber D, Remotti HE, Horowitz DP, Saenger YM. Gartrell RD, et al. Among authors: saenger ym. Oncoimmunology. 2022 May 5;11(1):2066767. doi: 10.1080/2162402X.2022.2066767. eCollection 2022. Oncoimmunology. 2022. PMID: 35558160 Free PMC article.
Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro-environment in transgenic BRAF murine melanoma.
Gartrell RD, Blake Z, Rizk EM, Perez-Lorenzo R, Weisberg SP, Simoes I, Esancy C, Fu Y, Davari DR, Barker L, Finkel G, Mondal M, Minns HE, Wang SW, Fullerton BT, Lozano F, Chiuzan C, Horst B, Saenger YM. Gartrell RD, et al. Among authors: saenger ym. Cancer Immunol Immunother. 2022 Aug;71(8):1837-1849. doi: 10.1007/s00262-021-03088-y. Epub 2022 Jan 9. Cancer Immunol Immunother. 2022. PMID: 34999916 Free PMC article.
40 results