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Activation of human STING by a molecular glue-like compound.
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y. Li J, et al. Among authors: feng y. Nat Chem Biol. 2024 Mar;20(3):365-372. doi: 10.1038/s41589-023-01434-y. Epub 2023 Oct 12. Nat Chem Biol. 2024. PMID: 37828400 Free PMC article.
Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action.
Wang AC, Pham HT, Lipps JM, Brittain SM, Harrington E, Wang Y, King FJ, Russ C, Pan X, Hoepfner D, Tallarico J, Feng Y, Jain RK, Schirle M, Thomas JR. Wang AC, et al. Among authors: feng y. ACS Chem Biol. 2019 Jan 18;14(1):20-26. doi: 10.1021/acschembio.8b00656. Epub 2018 Dec 18. ACS Chem Biol. 2019. PMID: 30461263
Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression.
Rothman DM, Gao X, George E, Rasmusson T, Bhatia D, Alimov I, Wang L, Kamel A, Hatsis P, Feng Y, Tutter A, Michaud G, McDonald E 3rd, Venkatesan K, Farley D, Digan ME, Ni Y, Harbinski F, Gunduz M, Wilson CJ, Buckler A, Labow M, Tallarico J, Myer VE, Porter JA, Wang S. Rothman DM, et al. Among authors: feng y. Chem Biol. 2015 Sep 17;22(9):1228-37. doi: 10.1016/j.chembiol.2015.06.025. Epub 2015 Sep 10. Chem Biol. 2015. PMID: 26364931
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, Bouwmeester T, Labow MA, Finan PM, Porter JA, Ploegh HL, Baird D, De Camilli P, Tallarico JA, Huang Q. Cai X, et al. Among authors: feng y. Chem Biol. 2013 Jul 25;20(7):912-21. doi: 10.1016/j.chembiol.2013.05.010. Chem Biol. 2013. PMID: 23890009 Free PMC article.
A Scalable Pipeline for High-Throughput Flow Cytometry.
Wilson AC, Moutsatsos IK, Yu G, Pineda JJ, Feng Y, Auld DS. Wilson AC, et al. Among authors: feng y. SLAS Discov. 2018 Aug;23(7):708-718. doi: 10.1177/2472555218774770. Epub 2018 May 16. SLAS Discov. 2018. PMID: 29768981 Free article.
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