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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.
Hanna SJ, Thayer TC, Robinson EJS, Vinh NN, Williams N, Landry LG, Andrews R, Siah QZ, Leete P, Wyatt R, McAteer MA, Nakayama M, Wong FS, Yang JHM, Tree TIM, Ludvigsson J, Dayan CM, Tatovic D. Hanna SJ, et al. Among authors: robinson ejs. Front Immunol. 2023 Oct 16;14:1276255. doi: 10.3389/fimmu.2023.1276255. eCollection 2023. Front Immunol. 2023. PMID: 37908349 Free PMC article.
Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype.
Hanna SJ, Powell WE, Long AE, Robinson EJS, Davies J, Megson C, Howell A, Jones TJ, Ladell K, Price DA, Dayan CM, Williams AJK, Gillespie KM, Wong FS. Hanna SJ, et al. Among authors: robinson ejs. Diabetologia. 2020 Jun;63(6):1174-1185. doi: 10.1007/s00125-020-05114-7. Epub 2020 Mar 10. Diabetologia. 2020. PMID: 32157332 Free PMC article.