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Heightened TLR7 signaling primes BCR-activated B cells in chronic graft-versus-host disease for effector functions.
Bracken SJ, Suthers AN, DiCioccio RA, Su H, Anand S, Poe JC, Jia W, Visentin J, Basher F, Jordan CZ, McManigle WC, Li Z, Hakim FT, Pavletic SZ, Bhuiya NS, Ho VT, Horwitz ME, Chao NJ, Sarantopoulos S. Bracken SJ, et al. Among authors: horwitz me. Blood Adv. 2024 Feb 13;8(3):667-680. doi: 10.1182/bloodadvances.2023010362. Blood Adv. 2024. PMID: 38113462 Free PMC article.
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
Poe JC, Jia W, Su H, Anand S, Rose JJ, Tata PV, Suthers AN, Jones CD, Kuan PF, Vincent BG, Serody JS, Horwitz ME, Ho VT, Pavletic SZ, Hakim FT, Owzar K, Zhang D, Blazar BR, Siebel CW, Chao NJ, Maillard I, Sarantopoulos S. Poe JC, et al. Among authors: horwitz me. Blood. 2017 Nov 9;130(19):2131-2145. doi: 10.1182/blood-2017-05-782466. Epub 2017 Aug 29. Blood. 2017. PMID: 28851699 Free PMC article. Clinical Trial.
Increased BCR responsiveness in B cells from patients with chronic GVHD.
Allen JL, Tata PV, Fore MS, Wooten J, Rudra S, Deal AM, Sharf A, Hoffert T, Roehrs PA, Shea TC, Serody JS, Richards KL, Jagasia M, Lee SJ, Rizzieri D, Horwitz ME, Chao NJ, Sarantopoulos S. Allen JL, et al. Among authors: horwitz me. Blood. 2014 Mar 27;123(13):2108-15. doi: 10.1182/blood-2013-10-533562. Epub 2014 Feb 14. Blood. 2014. PMID: 24532806 Free PMC article.
A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.
Lin C, DiCioccio RA, Haykal T, McManigle WC, Li Z, Anand SM, Poe JC, Bracken SJ, Jia W, Alyea EP 3rd, Cardones AR, Choi T, Gasparetto C, Grunwald MR, Hennig T, Kang Y, Long GD, Lopez R, Martin M, Minor KK, Quinones VLP, Sung AD, Wiggins K, Chao NJ, Horwitz ME, Rizzieri DA, Sarantopoulos S. Lin C, et al. Among authors: horwitz me. Transplant Cell Ther. 2023 Mar;29(3):179.e1-179.e10. doi: 10.1016/j.jtct.2022.12.015. Epub 2022 Dec 25. Transplant Cell Ther. 2023. PMID: 36577483 Free PMC article. Clinical Trial.
Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.
Poe JC, Fang J, Zhang D, Lee MR, DiCioccio RA, Su H, Qin X, Zhang JY, Visentin J, Bracken SJ, Ho VT, Wang KS, Rose JJ, Pavletic SZ, Hakim FT, Jia W, Suthers AN, Curry-Chisolm IM, Horwitz ME, Rizzieri DA, McManigle WC, Chao NJ, Cardones AR, Xie J, Owzar K, Sarantopoulos S. Poe JC, et al. Among authors: horwitz me. JCI Insight. 2023 Jun 8;8(11):e169732. doi: 10.1172/jci.insight.169732. JCI Insight. 2023. PMID: 37129971 Free PMC article.
Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.
Yamashita K, Choi U, Woltz PC, Foster SF, Sneller MC, Hakim FT, Fowler DH, Bishop MR, Pavletic SZ, Tamari M, Castro K, Barrett AJ, Childs RW, Illei GG, Leitman SF, Malech HL, Horwitz ME. Yamashita K, et al. Among authors: horwitz me. Blood. 2004 May 15;103(10):3986-8. doi: 10.1182/blood-2003-09-3286. Epub 2004 Feb 5. Blood. 2004. PMID: 14764530 Free article.
Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization.
Anand S, Thomas S, Hyslop T, Adcock J, Corbet K, Gasparetto C, Lopez R, Long GD, Morris AK, Rizzieri DA, Sullivan KM, Sung AD, Sarantopoulos S, Chao NJ, Horwitz ME. Anand S, et al. Among authors: horwitz me. Biol Blood Marrow Transplant. 2017 Jul;23(7):1151-1157. doi: 10.1016/j.bbmt.2017.04.001. Epub 2017 Apr 6. Biol Blood Marrow Transplant. 2017. PMID: 28392378 Free PMC article.
Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine Conditioning.
Anand S, Thomas S, Corbet K, Gasparetto C, Long GD, Lopez R, Morris AK, Rizzieri DA, Sullivan KM, Sung AD, Sarantopoulos S, Chao NJ, Horwitz ME. Anand S, et al. Among authors: horwitz me. Biol Blood Marrow Transplant. 2017 Nov;23(11):1949-1954. doi: 10.1016/j.bbmt.2017.06.027. Epub 2017 Jul 17. Biol Blood Marrow Transplant. 2017. PMID: 28729147 Free PMC article.
128 results