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Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling.
Lin SM, Rue R, Mukhitov AR, Goel A, Basil MC, Obraztsova K, Babu A, Crnkovic S, Ledwell OA, Ferguson LT, Planer JD, Nottingham AN, Vanka KS, Smith CJ, Cantu E 3rd, Kwapiszewska G, Morrisey EE, Evans JF, Krymskaya VP. Lin SM, et al. Among authors: babu a. J Clin Invest. 2023 Dec 20;134(4):e172116. doi: 10.1172/JCI172116. J Clin Invest. 2023. PMID: 38127441 Free PMC article.
Early lineage specification defines alveolar epithelial ontogeny in the murine lung.
Frank DB, Penkala IJ, Zepp JA, Sivakumar A, Linares-Saldana R, Zacharias WJ, Stolz KG, Pankin J, Lu M, Wang Q, Babu A, Li L, Zhou S, Morley MP, Jain R, Morrisey EE. Frank DB, et al. Among authors: babu a. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4362-4371. doi: 10.1073/pnas.1813952116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782824 Free PMC article.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP. Obraztsova K, et al. Among authors: babu a. Nat Commun. 2020 Nov 6;11(1):5640. doi: 10.1038/s41467-020-18979-4. Nat Commun. 2020. PMID: 33159078 Free PMC article.
Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus.
Zepp JA, Morley MP, Loebel C, Kremp MM, Chaudhry FN, Basil MC, Leach JP, Liberti DC, Niethamer TK, Ying Y, Jayachandran S, Babu A, Zhou S, Frank DB, Burdick JA, Morrisey EE. Zepp JA, et al. Among authors: babu a. Science. 2021 Mar 12;371(6534):eabc3172. doi: 10.1126/science.abc3172. Science. 2021. PMID: 33707239 Free PMC article.
Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Basil MC, et al. Among authors: babu a. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355013 Free PMC article.
GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells.
Fernandez RJ, Gardner ZJG, Slovik KJ, Liberti DC, Estep KN, Yang W, Chen Q, Santini GT, Perez JV, Root S, Bhatia R, Tobias JW, Babu A, Morley MP, Frank DB, Morrisey EE, Lengner CJ, Johnson FB. Fernandez RJ, et al. Among authors: babu a. Elife. 2022 May 13;11:e64430. doi: 10.7554/eLife.64430. Elife. 2022. PMID: 35559731 Free PMC article.
693 results