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Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
Wheeler EC, Martin BJE, Doyle WC, Neaher S, Conway CA, Pitton CN, Gorelov RA, Donahue M, Jann JC, Abdel-Wahab O, Taylor J, Seiler M, Buonamici S, Pikman Y, Garcia JS, Belizaire R, Adelman K, Tothova Z. Wheeler EC, et al. Among authors: donahue m. Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3. Sci Transl Med. 2024. PMID: 38170787
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Tothova Z, Valton AL, Gorelov RA, Vallurupalli M, Krill-Burger JM, Holmes A, Landers CC, Haydu JE, Malolepsza E, Hartigan C, Donahue M, Popova KD, Koochaki S, Venev SV, Rivera J, Chen E, Lage K, Schenone M, D'Andrea AD, Carr SA, Morgan EA, Dekker J, Ebert BL. Tothova Z, et al. Among authors: donahue m. JCI Insight. 2021 Feb 8;6(3):e142149. doi: 10.1172/jci.insight.142149. JCI Insight. 2021. PMID: 33351783 Free PMC article.
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, Khan M, Wadden D, Smith IC, Lam D, Liberzon A, Toder C, Bagul M, Orzechowski M, Enache OM, Piccioni F, Johnson SA, Lyons NJ, Berger AH, Shamji AF, Brooks AN, Vrcic A, Flynn C, Rosains J, Takeda DY, Hu R, Davison D, Lamb J, Ardlie K, Hogstrom L, Greenside P, Gray NS, Clemons PA, Silver S, Wu X, Zhao WN, Read-Button W, Wu X, Haggarty SJ, Ronco LV, Boehm JS, Schreiber SL, Doench JG, Bittker JA, Root DE, Wong B, Golub TR. Subramanian A, et al. Among authors: donahue m. Cell. 2017 Nov 30;171(6):1437-1452.e17. doi: 10.1016/j.cell.2017.10.049. Cell. 2017. PMID: 29195078 Free PMC article.
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Johannessen CM, Johnson LA, Piccioni F, Townes A, Frederick DT, Donahue MK, Narayan R, Flaherty KT, Wargo JA, Root DE, Garraway LA. Johannessen CM, et al. Among authors: donahue mk. Nature. 2013 Dec 5;504(7478):138-42. doi: 10.1038/nature12688. Epub 2013 Nov 3. Nature. 2013. PMID: 24185007 Free PMC article.
Durability of XBB.1.5 Vaccines against Omicron Subvariants.
Lin DY, Du Y, Xu Y, Paritala S, Donahue M, Maloney P. Lin DY, et al. Among authors: donahue m. N Engl J Med. 2024 May 29. doi: 10.1056/NEJMc2402779. Online ahead of print. N Engl J Med. 2024. PMID: 38810167 No abstract available.
Reduced cerebrospinal fluid motion in patients with Parkinson's disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging.
Pierobon Mays G, Hett K, Eisma J, McKnight CD, Elenberger J, Song AK, Considine C, Richerson WT, Han C, Stark A, Claassen DO, Donahue MJ. Pierobon Mays G, et al. Among authors: donahue mj. Fluids Barriers CNS. 2024 May 9;21(1):40. doi: 10.1186/s12987-024-00542-8. Fluids Barriers CNS. 2024. PMID: 38725029 Free PMC article.
589 results