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Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML.
Sci Transl Med. 2024 Jan 3;16(728):eade2774. doi: 10.1126/scitranslmed.ade2774. Epub 2024 Jan 3.
Sci Transl Med. 2024.
PMID: 38170787
Dissection of gastric homeostasis in vivo facilitates permanent capture of isthmus-like stem cells in vitro.
Huebner AJ, Gorelov RA, Deviatiiarov R, Demharter S, Kull T, Walsh RM, Taylor MS, Steiger S, Mullen JT, Kharchenko PV, Hochedlinger K.
Huebner AJ, et al. Among authors: gorelov ra.
Nat Cell Biol. 2023 Mar;25(3):390-403. doi: 10.1038/s41556-022-01079-4. Epub 2023 Jan 30.
Nat Cell Biol. 2023.
PMID: 36717627
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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.
Tothova Z, Valton AL, Gorelov RA, Vallurupalli M, Krill-Burger JM, Holmes A, Landers CC, Haydu JE, Malolepsza E, Hartigan C, Donahue M, Popova KD, Koochaki S, Venev SV, Rivera J, Chen E, Lage K, Schenone M, D'Andrea AD, Carr SA, Morgan EA, Dekker J, Ebert BL.
Tothova Z, et al. Among authors: gorelov ra.
JCI Insight. 2021 Feb 8;6(3):e142149. doi: 10.1172/jci.insight.142149.
JCI Insight. 2021.
PMID: 33351783
Free PMC article.
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BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation.
Miller DH, Jin DX, Sokol ES, Cabrera JR, Superville DA, Gorelov RA, Kuperwasser C, Gupta PB.
Miller DH, et al. Among authors: gorelov ra.
Stem Cell Reports. 2018 Mar 13;10(3):1131-1145. doi: 10.1016/j.stemcr.2018.01.036. Epub 2018 Mar 1.
Stem Cell Reports. 2018.
PMID: 29503088
Free PMC article.
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