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Differential microRNA editing may drive target pathway switching in human temporal lobe epilepsy.
Lau KEH, Nguyen NT, Kesavan JC, Langa E, Fanning K, Brennan GP, Sanz-Rodriguez A, Villegas-Salmerón J, Yan Y, Venø MT, Mills JD, Rosenow F, Bauer S, Kjems J, Henshall DC. Lau KEH, et al. Among authors: langa e. Brain Commun. 2024 Jan 3;6(1):fcad355. doi: 10.1093/braincomms/fcad355. eCollection 2024. Brain Commun. 2024. PMID: 38204971 Free PMC article.
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy.
Brindley E, Heiland M, Mooney C, Diviney M, Mamad O, Hill TDM, Yan Y, Venø MT, Reschke CR, Batool A, Langa E, Sanz-Rodriguez A, Heller JP, Morris G, Conboy K, Kjems J, Brennan GP, Henshall DC. Brindley E, et al. Among authors: langa e. Front Mol Neurosci. 2023 Sep 22;16:1230942. doi: 10.3389/fnmol.2023.1230942. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37808470 Free PMC article.
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC. Venø MT, et al. Among authors: langa e. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581127 Free PMC article.
AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome.
Campbell A, Morris G, Sanfeliu A, Augusto J, Langa E, Kesavan JC, Nguyen NT, Conroy RM, Worm J, Kielpinski L, Jensen MA, Miller MT, Kremer T, Reschke CR, Henshall DC. Campbell A, et al. Among authors: langa e. Mol Ther Nucleic Acids. 2022 Apr 20;28:514-529. doi: 10.1016/j.omtn.2022.04.009. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35592499 Free PMC article.
MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control.
Heiland M, Connolly NMC, Mamad O, Nguyen NT, Kesavan JC, Langa E, Fanning K, Sanfeliu A, Yan Y, Su J, Venø MT, Costard LS, Neubert V, Engel T, Hill TDM, Freiman TM, Mahesh A, Tiwari VK, Rosenow F, Bauer S, Kjems J, Morris G, Henshall DC. Heiland M, et al. Among authors: langa e. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216658120. doi: 10.1073/pnas.2216658120. Epub 2023 Jul 18. Proc Natl Acad Sci U S A. 2023. PMID: 37463203 Free PMC article.
MicroRNA inhibition using antimiRs in acute human brain tissue sections.
Morris G, Langa E, Fearon C, Conboy K, Lau E-How K, Sanz-Rodriguez A, O'Brien DF, Sweeney K, Lacey A, Delanty N, Beausang A, Brett FM, Cryan JB, Cunningham MO, Henshall DC. Morris G, et al. Among authors: langa e. Epilepsia. 2022 Aug;63(8):e92-e99. doi: 10.1111/epi.17317. Epub 2022 Jun 20. Epilepsia. 2022. PMID: 35656590 Free PMC article.
44 results