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Page 1
Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice.
Mamad O, Heiland M, Lindner AU, Hill TDM, Ronroy RM, Rentrup K, Sanz-Rodriguez A, Langa E, Heller JP, Moreno O, Llop J, Bhattacharya A, Palmer JA, Ceusters M, Engel T, Henshall DC. Mamad O, et al. Among authors: sanz rodriguez a. Front Pharmacol. 2024 Jan 8;14:1308478. doi: 10.3389/fphar.2023.1308478. eCollection 2023. Front Pharmacol. 2024. PMID: 38259288 Free PMC article.
Differential microRNA editing may drive target pathway switching in human temporal lobe epilepsy.
Lau KEH, Nguyen NT, Kesavan JC, Langa E, Fanning K, Brennan GP, Sanz-Rodriguez A, Villegas-Salmerón J, Yan Y, Venø MT, Mills JD, Rosenow F, Bauer S, Kjems J, Henshall DC. Lau KEH, et al. Among authors: sanz rodriguez a. Brain Commun. 2024 Jan 3;6(1):fcad355. doi: 10.1093/braincomms/fcad355. eCollection 2024. Brain Commun. 2024. PMID: 38204971 Free PMC article.
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy.
Brindley E, Heiland M, Mooney C, Diviney M, Mamad O, Hill TDM, Yan Y, Venø MT, Reschke CR, Batool A, Langa E, Sanz-Rodriguez A, Heller JP, Morris G, Conboy K, Kjems J, Brennan GP, Henshall DC. Brindley E, et al. Among authors: sanz rodriguez a. Front Mol Neurosci. 2023 Sep 22;16:1230942. doi: 10.3389/fnmol.2023.1230942. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37808470 Free PMC article.
MicroRNA inhibition using antimiRs in acute human brain tissue sections.
Morris G, Langa E, Fearon C, Conboy K, Lau E-How K, Sanz-Rodriguez A, O'Brien DF, Sweeney K, Lacey A, Delanty N, Beausang A, Brett FM, Cryan JB, Cunningham MO, Henshall DC. Morris G, et al. Among authors: sanz rodriguez a. Epilepsia. 2022 Aug;63(8):e92-e99. doi: 10.1111/epi.17317. Epub 2022 Jun 20. Epilepsia. 2022. PMID: 35656590 Free PMC article.
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.
Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC. Reschke CR, et al. Among authors: sanz rodriguez a. Mol Ther. 2021 Jun 2;29(6):2041-2052. doi: 10.1016/j.ymthe.2021.02.021. Epub 2021 Feb 18. Mol Ther. 2021. PMID: 33609732 Free PMC article.
Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice.
Almeida Silva LF, Reschke CR, Nguyen NT, Langa E, Sanz-Rodriguez A, Gerbatin RR, Temp FR, de Freitas ML, Conroy RM, Brennan GP, Engel T, Henshall DC. Almeida Silva LF, et al. Among authors: sanz rodriguez a. Mol Brain. 2020 Aug 21;13(1):114. doi: 10.1186/s13041-020-00653-x. Mol Brain. 2020. PMID: 32825833 Free PMC article.
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy.
Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F, Henshall DC. Brennan GP, et al. Among authors: sanz rodriguez a. Neurobiol Dis. 2020 Oct;144:105048. doi: 10.1016/j.nbd.2020.105048. Epub 2020 Aug 13. Neurobiol Dis. 2020. PMID: 32800995 Free article.
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC. Venø MT, et al. Among authors: sanz rodriguez a. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581127 Free PMC article.
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