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Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates.
Ray M, Zaborowsky J, Mahableshwarkar P, Vaidyanathan S, Shum J, Viswanathan R, Huang A, Wang SH, Johnson V, Wake N, Conard AM, Conicella AE, Puterbaugh R, Fawzi NL, Larschan E. Ray M, et al. Among authors: conicella ae. bioRxiv [Preprint]. 2024 Jan 12:2024.01.11.575216. doi: 10.1101/2024.01.11.575216. bioRxiv. 2024. PMID: 38260450 Free PMC article. Preprint.
TDP-43 α-helical structure tunes liquid-liquid phase separation and function.
Conicella AE, Dignon GL, Zerze GH, Schmidt HB, D'Ordine AM, Kim YC, Rohatgi R, Ayala YM, Mittal J, Fawzi NL. Conicella AE, et al. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5883-5894. doi: 10.1073/pnas.1912055117. Epub 2020 Mar 4. Proc Natl Acad Sci U S A. 2020. PMID: 32132204 Free PMC article.
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chiò A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A. Fratta P, et al. Among authors: conicella ae. EMBO J. 2018 Jun 1;37(11):e98684. doi: 10.15252/embj.201798684. Epub 2018 May 15. EMBO J. 2018. PMID: 29764981 Free PMC article.
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