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NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K. Coombs JR, et al. Among authors: mellacheruvu m. Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23. Sci Signal. 2024. PMID: 38261657
Reversing the mitochondrial hex that bewitches NLRP3.
Mellacheruvu M, Lawrence GMEP, Emming S, Schroder K. Mellacheruvu M, et al. Sci Immunol. 2023 Jun 23;8(84):eadh2967. doi: 10.1126/sciimmunol.adh2967. Epub 2023 Jun 16. Sci Immunol. 2023. PMID: 37327323 Review.