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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318024121. doi: 10.1073/pnas.2318024121. Epub 2024 Feb 8.
Proc Natl Acad Sci U S A. 2024.
PMID: 38330014
Free PMC article.
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Abrams ME, Johnson KA, Perelman SS, Zhang LS, Endapally S, Mar KB, Thompson BM, McDonald JG, Schoggins JW, Radhakrishnan A, Alto NM.
Abrams ME, et al. Among authors: endapally s.
Nat Microbiol. 2020 Jul;5(7):929-942. doi: 10.1038/s41564-020-0701-5. Epub 2020 Apr 13.
Nat Microbiol. 2020.
PMID: 32284563
Free PMC article.
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Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum.
Johnson KA, Endapally S, Vazquez DC, Infante RE, Radhakrishnan A.
Johnson KA, et al. Among authors: endapally s.
J Biol Chem. 2019 Nov 15;294(46):17289-17300. doi: 10.1074/jbc.RA119.010393. Epub 2019 Oct 9.
J Biol Chem. 2019.
PMID: 31597703
Free PMC article.
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Monitoring and Modulating Intracellular Cholesterol Trafficking Using ALOD4, a Cholesterol-Binding Protein.
Endapally S, Infante RE, Radhakrishnan A.
Endapally S, et al.
Methods Mol Biol. 2019;1949:153-163. doi: 10.1007/978-1-4939-9136-5_12.
Methods Mol Biol. 2019.
PMID: 30790255
Free PMC article.
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Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes.
Endapally S, Frias D, Grzemska M, Gay A, Tomchick DR, Radhakrishnan A.
Endapally S, et al.
Cell. 2019 Feb 21;176(5):1040-1053.e17. doi: 10.1016/j.cell.2018.12.042. Epub 2019 Jan 31.
Cell. 2019.
PMID: 30712872
Free PMC article.
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