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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Xu S, Smothers JC, Rye D, Endapally S, Chen H, Li S, Liang G, Kinnebrew M, Rohatgi R, Posner BA, Radhakrishnan A. Xu S, et al. Among authors: rohatgi r. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318024121. doi: 10.1073/pnas.2318024121. Epub 2024 Feb 8. Proc Natl Acad Sci U S A. 2024. PMID: 38330014 Free PMC article.
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: rohatgi r. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Kinnebrew M, et al. Among authors: rohatgi r. Elife. 2019 Oct 30;8:e50051. doi: 10.7554/eLife.50051. Elife. 2019. PMID: 31657721 Free PMC article.
Cholesterol access in cellular membranes controls Hedgehog signaling.
Radhakrishnan A, Rohatgi R, Siebold C. Radhakrishnan A, et al. Among authors: rohatgi r. Nat Chem Biol. 2020 Dec;16(12):1303-1313. doi: 10.1038/s41589-020-00678-2. Epub 2020 Nov 16. Nat Chem Biol. 2020. PMID: 33199907 Free PMC article. Review.
Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.
Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. Gokhman D, et al. Among authors: rohatgi r. Nat Genet. 2021 Apr;53(4):467-476. doi: 10.1038/s41588-021-00804-3. Epub 2021 Mar 17. Nat Genet. 2021. PMID: 33731941 Free PMC article.
164 results