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Basophils are important for development of allergic skin inflammation.
Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Leyva-Castillo JM, et al. Among authors: strakosha m. J Allergy Clin Immunol. 2024 May;153(5):1344-1354.e5. doi: 10.1016/j.jaci.2024.01.022. Epub 2024 Feb 7. J Allergy Clin Immunol. 2024. PMID: 38336257
IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin.
Leyva-Castillo JM, McGurk A, Strakosha M, Vega-Mendoza D, Smith SEM, Stafstrom K, Elkins M, Chou J, Wang YH, Geha RS. Leyva-Castillo JM, et al. Among authors: strakosha m. J Allergy Clin Immunol. 2023 Oct;152(4):907-915. doi: 10.1016/j.jaci.2023.05.025. Epub 2023 Jun 12. J Allergy Clin Immunol. 2023. PMID: 37315811
Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection.
Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS. Leyva-Castillo JM, et al. Among authors: strakosha m. JCI Insight. 2021 Nov 8;6(21):e149953. doi: 10.1172/jci.insight.149953. JCI Insight. 2021. PMID: 34747366 Free PMC article.