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Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.
Aloisio GM, Nagaraj D, Murray AM, Schultz EM, McBride T, Aideyan L, Nicholson EG, Henke D, Ferlic-Stark L, Rajan A, Kambal A, Johnson HL, Mosa E, Stossi F, Blutt SE, Piedra PA, Avadhanula V. Aloisio GM, et al. bioRxiv [Preprint]. 2024 Feb 1:2024.02.01.578466. doi: 10.1101/2024.02.01.578466. bioRxiv. 2024. PMID: 38352333 Free PMC article. Preprint.
The human nose organoid respiratory virus model: an ex-vivo human challenge model to study RSV and SARS-CoV-2 pathogenesis and evaluate therapeutics.
Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA. Rajan A, et al. Among authors: aloisio gm. bioRxiv [Preprint]. 2021 Jul 28:2021.07.28.453844. doi: 10.1101/2021.07.28.453844. bioRxiv. 2021. PMID: 34341793 Free PMC article. Updated. Preprint.
Multiple Respiratory Syncytial Virus (RSV) Strains Infecting HEp-2 and A549 Cells Reveal Cell Line-Dependent Differences in Resistance to RSV Infection.
Rajan A, Piedra FA, Aideyan L, McBride T, Robertson M, Johnson HL, Aloisio GM, Henke D, Coarfa C, Stossi F, Menon VK, Doddapaneni H, Muzny DM, Javornik Cregeen SJ, Hoffman KL, Petrosino J, Gibbs RA, Avadhanula V, Piedra PA. Rajan A, et al. Among authors: aloisio gm. J Virol. 2022 Apr 13;96(7):e0190421. doi: 10.1128/jvi.01904-21. Epub 2022 Mar 14. J Virol. 2022. PMID: 35285685 Free PMC article.
The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics.
Rajan A, Weaver AM, Aloisio GM, Jelinski J, Johnson HL, Venable SF, McBride T, Aideyan L, Piedra FA, Ye X, Melicoff-Portillo E, Yerramilli MRK, Zeng XL, Mancini MA, Stossi F, Maresso AW, Kotkar SA, Estes MK, Blutt S, Avadhanula V, Piedra PA. Rajan A, et al. Among authors: aloisio gm. mBio. 2021 Feb 22;13(1):e0351121. doi: 10.1128/mbio.03511-21. Epub 2022 Feb 15. mBio. 2021. PMID: 35164569 Free PMC article.
PAX7 expression defines germline stem cells in the adult testis.
Aloisio GM, Nakada Y, Saatcioglu HD, Peña CG, Baker MD, Tarnawa ED, Mukherjee J, Manjunath H, Bugde A, Sengupta AL, Amatruda JF, Cuevas I, Hamra FK, Castrillon DH. Aloisio GM, et al. J Clin Invest. 2014 Sep;124(9):3929-44. doi: 10.1172/JCI75943. Epub 2014 Aug 18. J Clin Invest. 2014. PMID: 25133429 Free PMC article.
The small GTPase Rheb is required for spermatogenesis but not oogenesis.
Baker MD, Ezzati M, Aloisio GM, Tarnawa ED, Cuevas I, Nakada Y, Castrillon DH. Baker MD, et al. Among authors: aloisio gm. Reproduction. 2014 Apr 8;147(5):615-25. doi: 10.1530/REP-13-0304. Print 2014 May. Reproduction. 2014. PMID: 24713393 Free PMC article.
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