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WNT signalling control by KDM5C during development affects cognition.
Karwacki-Neisius V, Jang A, Cukuroglu E, Tai A, Jiao A, Predes D, Yoon J, Brookes E, Chen J, Iberg A, Halbritter F, Õunap K, Gecz J, Schlaeger TM, Ho Sui S, Göke J, He X, Lehtinen MK, Pomeroy SL, Shi Y. Karwacki-Neisius V, et al. Among authors: chen j. Nature. 2024 Mar;627(8004):594-603. doi: 10.1038/s41586-024-07067-y. Epub 2024 Feb 21. Nature. 2024. PMID: 38383780 Free PMC article.
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.
Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J, Yao H, Chen J, Pei D, Pan G. Shan Y, et al. Among authors: chen j, chen q. Nat Commun. 2017 Sep 22;8(1):672. doi: 10.1038/s41467-017-00668-4. Nat Commun. 2017. PMID: 28939884 Free PMC article.
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, Liang H, Chen Y, Chen J, Wu Y, Guo L, Zhu J, Zhao X, Peng T, Zhang Y, Chen S, Li X, Li D, Wang T, Pei D. Chen J, et al. Among authors: chen s, chen y. Nat Genet. 2013 Jan;45(1):34-42. doi: 10.1038/ng.2491. Epub 2012 Dec 2. Nat Genet. 2013. PMID: 23202127
Vitamin C modulates TET1 function during somatic cell reprogramming.
Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao SQ, Mo K, Li Y, Lai K, Qi J, Yao H, Pan G, Xu GL, Pei D. Chen J, et al. Nat Genet. 2013 Dec;45(12):1504-9. doi: 10.1038/ng.2807. Epub 2013 Oct 27. Nat Genet. 2013. PMID: 24162740
The oncogene c-Jun impedes somatic cell reprogramming.
Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D. Liu J, et al. Among authors: chen j, chen y. Nat Cell Biol. 2015 Jul;17(7):856-67. doi: 10.1038/ncb3193. Epub 2015 Jun 22. Nat Cell Biol. 2015. PMID: 26098572
BMI1 enables interspecies chimerism with human pluripotent stem cells.
Huang K, Zhu Y, Ma Y, Zhao B, Fan N, Li Y, Song H, Chu S, Ouyang Z, Zhang Q, Xing Q, Lai C, Li N, Zhang T, Gu J, Kang B, Shan Y, Lai K, Huang W, Mai Y, Wang Q, Li J, Lin A, Zhang Y, Zhong X, Liao B, Lai L, Chen J, Pei D, Pan G. Huang K, et al. Among authors: chen j. Nat Commun. 2018 Nov 7;9(1):4649. doi: 10.1038/s41467-018-07098-w. Nat Commun. 2018. PMID: 30405129 Free PMC article.
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling.
Yu S, Zhou C, Cao S, He J, Cai B, Wu K, Qin Y, Huang X, Xiao L, Ye J, Xu S, Xie W, Kuang J, Chu S, Guo J, Liu H, Pang W, Guo L, Zeng M, Wang X, Luo R, Li C, Zhao G, Wang B, Wu L, Chen J, Liu J, Pei D. Yu S, et al. Among authors: chen j. Nat Cell Biol. 2020 Jun;22(6):651-662. doi: 10.1038/s41556-020-0516-x. Epub 2020 May 11. Nat Cell Biol. 2020. PMID: 32393886
The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity.
Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J. Liu J, et al. Among authors: chen j, chen y. Nature. 2021 Mar;591(7849):322-326. doi: 10.1038/s41586-021-03313-9. Epub 2021 Mar 3. Nature. 2021. PMID: 33658714
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