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Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis.
Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB, Carroll TJ, Modrusan Z, Durinck S, Requena-Komuro MC, Williams NS, Pedrosa I, Wang T, Rakheja D, Kapur P, Brugarolas J. Prakasam G, et al. Among authors: williams ns. J Clin Invest. 2024 Feb 22;134(7):e170559. doi: 10.1172/JCI170559. J Clin Invest. 2024. PMID: 38386415 Free PMC article.
Thiophenyl Derivatives of Nicotinamide Are Metabolized by the NAD Salvage Pathway into Unnatural NAD Derivatives That Inhibit IMPDH and Are Toxic to Peripheral Nerve Cancers.
Theodoropoulos PC, Guo HH, Wang W, Crossley E, Rivera Cancel G, Fang M, Nguyen T, Baniasadi H, Williams NS, Ready JM, De Brabander JK, Nijhawan D. Theodoropoulos PC, et al. Among authors: williams ns. ACS Chem Biol. 2024 Jun 3. doi: 10.1021/acschembio.4c00170. Online ahead of print. ACS Chem Biol. 2024. PMID: 38829020
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PAS, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes Dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M. Venkateswaran N, et al. Among authors: williams ns. Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3. Nat Commun. 2024. PMID: 38769298 Free PMC article.
Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.
Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ. Rosenthal ZC, et al. Among authors: williams ns. Sci Rep. 2024 Apr 20;14(1):9064. doi: 10.1038/s41598-024-59110-7. Sci Rep. 2024. PMID: 38643236 Free PMC article.
Targeting of neuroblastoma cells through Kynurenine-AHR pathway inhibition.
Dos Santos IL, Mitchell M, Nogueira PAS, Lafita-Navarro MC, Perez-Castro L, Eriom J, Kilgore JA, Williams NS, Guo L, Xu L, Conacci-Sorrell M. Dos Santos IL, et al. Among authors: williams ns. FEBS J. 2024 May;291(10):2172-2190. doi: 10.1111/febs.17109. Epub 2024 Mar 3. FEBS J. 2024. PMID: 38431776
Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance.
Rodrigues M, Sabaeifard P, Yildiz MS, Lyon A, Coughlin L, Ahmed S, Poulides N, Toprak AC, Behrendt C, Wang X, Monogue M, Kim J, Gan S, Zhan X, Filkins L, Williams NS, Hooper LV, Koh AY, Toprak E. Rodrigues M, et al. Among authors: williams ns. Cell Host Microbe. 2024 Mar 13;32(3):396-410.e6. doi: 10.1016/j.chom.2024.01.012. Epub 2024 Feb 14. Cell Host Microbe. 2024. PMID: 38359828
413 results