Cossar PJ - Search Results

1

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

Katz LS, Visser EJ, Plitzko KF, Pennings M, Cossar PJ, Tse IL, Kaiser M, Brunsveld L, Scott DK, Ottmann C. Katz LS, et al. Among authors: cossar pj. bioRxiv [Preprint]. 2024 Feb 17:2024.02.16.580675. doi: 10.1101/2024.02.16.580675. bioRxiv. 2024. PMID: 38405965 Free PMC article. Preprint.

2

A simple method for developing lysine targeted covalent protein reagents.

Gabizon R, Tivon B, Reddi RN, van den Oetelaar MCM, Amartely H, Cossar PJ, Ottmann C, London N. Gabizon R, et al. Among authors: cossar pj. Nat Commun. 2023 Dec 1;14(1):7933. doi: 10.1038/s41467-023-42632-5. Nat Commun. 2023. PMID: 38040731 Free PMC article.

3

Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer.

Sun J, Baker JR, Russell CC, Pham HNT, Goldsmith CD, Cossar PJ, Sakoff JA, Scarlett CJ, McCluskey A. Sun J, et al. Among authors: cossar pj. RSC Med Chem. 2023 Jul 5;14(11):2246-2267. doi: 10.1039/d2md00289b. eCollection 2023 Nov 15. RSC Med Chem. 2023. PMID: 37974967

4

Discovery of 14-3-3 PPI Stabilizers by Extension of an Amidine-Substituted Thiophene Fragment.

Wu Q, Centorrino F, Guillory X, Wolter M, Ottmann C, Cossar PJ, Brunsveld L. Wu Q, et al. Among authors: cossar pj. Chembiochem. 2024 Jan 2;25(1):e202300636. doi: 10.1002/cbic.202300636. Epub 2023 Nov 17. Chembiochem. 2024. PMID: 37902676

5

Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry.

Verhoef CJA, Kay DF, van Dijck L, Doveston RG, Brunsveld L, Leney AC, Cossar PJ. Verhoef CJA, et al. Among authors: cossar pj. Chem Sci. 2023 May 31;14(24):6756-6762. doi: 10.1039/d3sc01732j. eCollection 2023 Jun 21. Chem Sci. 2023. PMID: 37350830 Free PMC article.

6

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex.

Somsen BA, Sijbesma E, Leysen S, Honzejkova K, Visser EJ, Cossar PJ, Obšil T, Brunsveld L, Ottmann C. Somsen BA, et al. Among authors: cossar pj. J Biol Chem. 2023 Jul;299(7):104855. doi: 10.1016/j.jbc.2023.104855. Epub 2023 May 22. J Biol Chem. 2023. PMID: 37224961 Free PMC article.

7

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.

Somsen BA, Schellekens RJC, Verhoef CJA, Arkin MR, Ottmann C, Cossar PJ, Brunsveld L. Somsen BA, et al. Among authors: cossar pj. J Am Chem Soc. 2023 Mar 29;145(12):6741-6752. doi: 10.1021/jacs.2c12781. Epub 2023 Mar 16. J Am Chem Soc. 2023. PMID: 36926879 Free PMC article.

8

Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis.

Cossar PJ, Cardoso D, Mathwin D, Russell CC, Chiew B, Hamilton MP, Baker JR, Young KA, Chau N, Robinson PJ, McCluskey A. Cossar PJ, et al. Eur J Med Chem. 2023 Feb 5;247:115001. doi: 10.1016/j.ejmech.2022.115001. Epub 2022 Dec 15. Eur J Med Chem. 2023. PMID: 36577213

9

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues.

Somsen BA, Craenmehr FWB, Liu WW, Koops AA, Pennings MAM, Visser EJ, Ottmann C, Cossar PJ, Brunsveld L. Somsen BA, et al. Among authors: cossar pj. Chem Sci. 2022 Oct 25;13(44):13122-13131. doi: 10.1039/d2sc04662h. eCollection 2022 Nov 16. Chem Sci. 2022. PMID: 36425501 Free PMC article.

10

Amino Alcohols as Potential Antibiotic and Antifungal Leads.

Baker JR, Cossar PJ, Blaskovich MAT, Elliott AG, Zuegg J, Cooper MA, Lewis PJ, McCluskey A. Baker JR, et al. Among authors: cossar pj. Molecules. 2022 Mar 22;27(7):2050. doi: 10.3390/molecules27072050. Molecules. 2022. PMID: 35408448 Free PMC article.

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