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VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model.
Boisserand LSB, Geraldo LH, Bouchart J, El Kamouh MR, Lee S, Sanganahalli BG, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Saceanu Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez SE, Singhabahu R, Robinson ME, Askenase MH, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing LH, Benveniste H, Hyder F, Thomas JL. Boisserand LSB, et al. Among authors: eichmann a. J Exp Med. 2024 Apr 1;221(4):e20221983. doi: 10.1084/jem.20221983. Epub 2024 Mar 5. J Exp Med. 2024. PMID: 38442272 Free PMC article.
A model for gene therapy of human hereditary lymphedema.
Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K. Karkkainen MJ, et al. Among authors: eichmann a. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12677-82. doi: 10.1073/pnas.221449198. Epub 2001 Oct 9. Proc Natl Acad Sci U S A. 2001. PMID: 11592985 Free PMC article.
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. Le Bras B, et al. Among authors: eichmann a. Nat Neurosci. 2006 Mar;9(3):340-8. doi: 10.1038/nn1646. Epub 2006 Feb 5. Nat Neurosci. 2006. PMID: 16462734
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A. Xu Y, et al. Among authors: eichmann a. J Cell Biol. 2010 Jan 11;188(1):115-30. doi: 10.1083/jcb.200903137. J Cell Biol. 2010. PMID: 20065093 Free PMC article.
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL. Calvo CF, et al. Among authors: eichmann a. Genes Dev. 2011 Apr 15;25(8):831-44. doi: 10.1101/gad.615311. Genes Dev. 2011. PMID: 21498572 Free PMC article.
Molecular parallels between neural and vascular development.
Eichmann A, Thomas JL. Eichmann A, et al. Cold Spring Harb Perspect Med. 2013 Jan 1;3(1):a006551. doi: 10.1101/cshperspect.a006551. Cold Spring Harb Perspect Med. 2013. PMID: 23024177 Free PMC article. Review.
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