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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
Terrett JA, Ly JQ, Katavolos P, Hasselgren C, Laing S, Zhong F, Villemure E, Déry M, Larouche-Gauthier R, Chen H, Shore DG, Lee WP, Suto E, Johnson K, Brooks M, Stablein A, Beaumier F, Constantineau-Forget L, Grand-Maître C, Lépissier L, Ciblat S, Sturino C, Chen Y, Hu B, Elstrott J, Gandham V, Joseph V, Booler H, Cain G, Chou C, Fullerton A, Lepherd M, Stainton S, Torres E, Urban K, Yu L, Zhong Y, Bao L, Chou KJ, Lin J, Zhang W, La H, Liu L, Mulder T, Chen J, Chernov-Rogan T, Johnson AR, Hackos DH, Leahey R, Shields SD, Balestrini A, Riol-Blanco L, Safina BS, Volgraf M, Magnuson S, Kakiuchi-Kiyota S. Terrett JA, et al. Among authors: shore dg. J Med Chem. 2024 Mar 14;67(5):3287-3306. doi: 10.1021/acs.jmedchem.3c02121. Epub 2024 Mar 3. J Med Chem. 2024. PMID: 38431835
K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ).
Suresh HG, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, David Masinas MP, Shuteriqi E, Shore D, Henras AK, Thibault P, Boone C, Andrews BJ. Suresh HG, et al. Among authors: shore d. bioRxiv [Preprint]. 2023 May 4:2023.05.03.539259. doi: 10.1101/2023.05.03.539259. bioRxiv. 2023. PMID: 37205480 Free PMC article. Preprint.
CD19 CAR antigen engagement mechanisms and affinity tuning.
He C, Mansilla-Soto J, Khanra N, Hamieh M, Bustos V, Paquette AJ, Garcia Angus A, Shore DM, Rice WJ, Khelashvili G, Sadelain M, Meyerson JR. He C, et al. Among authors: shore dm. Sci Immunol. 2023 Mar 10;8(81):eadf1426. doi: 10.1126/sciimmunol.adf1426. Epub 2023 Mar 3. Sci Immunol. 2023. PMID: 36867678 Free PMC article.
Bioapplications of Magnetic Nanowires: Barcodes, Biocomposites, Heaters.
Kouhpanji MRZ, Zhang Y, Um J, Srinivasan K, Sharma A, Shore D, Gao Z, Chen Y, Harpel A, Porshokouh ZN, Gage TE, Dragos-Pinzaru O, Tabakovic I, Visscher PB, Bischof J, Modiano JF, Franklin R, Stadler BJH. Kouhpanji MRZ, et al. Among authors: shore d. IEEE Trans Magn. 2022 Aug;58(8):5200406. doi: 10.1109/tmag.2022.3151608. Epub 2022 Feb 23. IEEE Trans Magn. 2022. PMID: 36864851 Free PMC article.
473 results