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ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.
Schmid S, Russell ZR, Yamashita AS, West ME, Parrish AG, Walker J, Rudoy D, Yan JZ, Quist DC, Gessesse BN, Alvinez N, Cimino PJ, Kumasaka DK, Parchment RE, Holland EC, Szulzewsky F. Schmid S, et al. Among authors: szulzewsky f. bioRxiv [Preprint]. 2024 Mar 26:2024.03.13.584849. doi: 10.1101/2024.03.13.584849. bioRxiv. 2024. PMID: 38558981 Free PMC article. Preprint.
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.
Cimino PJ, Kim Y, Wu HJ, Alexander J, Wirsching HG, Szulzewsky F, Pitter K, Ozawa T, Wang J, Vazquez J, Arora S, Rabadan R, Levine R, Michor F, Holland EC. Cimino PJ, et al. Among authors: szulzewsky f. Genes Dev. 2018 Apr 1;32(7-8):512-523. doi: 10.1101/gad.312157.118. Epub 2018 Apr 9. Genes Dev. 2018. PMID: 29632085 Free PMC article.
Anti-PD-L1 antibody direct activation of macrophages contributes to a radiation-induced abscopal response in glioblastoma.
Ene CI, Kreuser SA, Jung M, Zhang H, Arora S, White Moyes K, Szulzewsky F, Barber J, Cimino PJ, Wirsching HG, Patel A, Kong P, Woodiwiss TR, Durfy SJ, Houghton AM, Pierce RH, Parney IF, Crane CA, Holland EC. Ene CI, et al. Among authors: szulzewsky f. Neuro Oncol. 2020 May 15;22(5):639-651. doi: 10.1093/neuonc/noz226. Neuro Oncol. 2020. PMID: 31793634 Free PMC article.
A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Pattwell SS, Arora S, Cimino PJ, Ozawa T, Szulzewsky F, Hoellerbauer P, Bonifert T, Hoffstrom BG, Boiani NE, Bolouri H, Correnti CE, Oldrini B, Silber JR, Squatrito M, Paddison PJ, Holland EC. Pattwell SS, et al. Among authors: szulzewsky f. Nat Commun. 2020 Jun 12;11(1):2977. doi: 10.1038/s41467-020-16786-5. Nat Commun. 2020. PMID: 32532995 Free PMC article.
Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma.
Alexander J, LaPlant QC, Pattwell SS, Szulzewsky F, Cimino PJ, Caruso FP, Pugliese P, Chen Z, Chardon F, Hill AJ, Spurrell C, Ahrendsen D, Pietras A, Starita LM, Hambardzumyan D, Iavarone A, Shendure J, Holland EC. Alexander J, et al. Among authors: szulzewsky f. Glia. 2020 Dec;68(12):2486-2502. doi: 10.1002/glia.23866. Epub 2020 Jul 4. Glia. 2020. PMID: 32621641 Free PMC article.
47 results