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Utilizing multimodal AI to improve genetic analyses of cardiovascular traits.
Zhou Y, Cosentino J, Yun T, Biradar MI, Shreibati J, Lai D, Schwantes-An TH, Luben R, McCaw Z, Engmann J, Providencia R, Schmidt AF, Munroe P, Yang H, Carroll A, Khawaja AP, McLean CY, Behsaz B, Hormozdiari F. Zhou Y, et al. Among authors: mclean cy. medRxiv [Preprint]. 2024 Mar 20:2024.03.19.24304547. doi: 10.1101/2024.03.19.24304547. medRxiv. 2024. PMID: 38562791 Free PMC article. Preprint.
Unsupervised representation learning improves genomic discovery and risk prediction for respiratory and circulatory functions and diseases.
Yun T, Cosentino J, Behsaz B, McCaw ZR, Hill D, Luben R, Lai D, Bates J, Yang H, Schwantes-An TH, Zhou Y, Khawaja AP, Carroll A, Hobbs BD, Cho MH, McLean CY, Hormozdiari F. Yun T, et al. Among authors: mclean cy. medRxiv [Preprint]. 2023 Aug 29:2023.04.28.23289285. doi: 10.1101/2023.04.28.23289285. medRxiv. 2023. PMID: 37163049 Free PMC article. Preprint.
DeepConsensus improves the accuracy of sequences with a gap-aware sequence transformer.
Baid G, Cook DE, Shafin K, Yun T, Llinares-López F, Berthet Q, Belyaeva A, Töpfer A, Wenger AM, Rowell WJ, Yang H, Kolesnikov A, Ammar W, Vert JP, Vaswani A, McLean CY, Nattestad M, Chang PC, Carroll A. Baid G, et al. Among authors: mclean cy. Nat Biotechnol. 2023 Feb;41(2):232-238. doi: 10.1038/s41587-022-01435-7. Epub 2022 Sep 1. Nat Biotechnol. 2023. PMID: 36050551
A population-specific reference panel for improved genotype imputation in African Americans.
O'Connell J, Yun T, Moreno M, Li H, Litterman N, Kolesnikov A, Noblin E, Chang PC, Shastri A, Dorfman EH, Shringarpure S; 23andMe Research Team; Auton A, Carroll A, McLean CY. O'Connell J, et al. Among authors: mclean cy. Commun Biol. 2021 Nov 5;4(1):1269. doi: 10.1038/s42003-021-02777-9. Commun Biol. 2021. PMID: 34741098 Free PMC article.
Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology.
Alipanahi B, Hormozdiari F, Behsaz B, Cosentino J, McCaw ZR, Schorsch E, Sculley D, Dorfman EH, Foster PJ, Peng LH, Phene S, Hammel N, Carroll A, Khawaja AP, McLean CY. Alipanahi B, et al. Among authors: mclean cy. Am J Hum Genet. 2021 Jul 1;108(7):1217-1230. doi: 10.1016/j.ajhg.2021.05.004. Epub 2021 Jun 1. Am J Hum Genet. 2021. PMID: 34077760 Free PMC article.
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Lai D, Alipanahi B, Fontanillas P, Schwantes-An TH, Aasly J, Alcalay RN, Beecham GW, Berg D, Bressman S, Brice A, Brockman K, Clark L, Cookson M, Das S, Van Deerlin V, Follett J, Farrer MJ, Trinh J, Gasser T, Goldwurm S, Gustavsson E, Klein C, Lang AE, Langston JW, Latourelle J, Lynch T, Marder K, Marras C, Martin ER, McLean CY, Mejia-Santana H, Molho E, Myers RH, Nuytemans K, Ozelius L, Payami H, Raymond D, Rogaeva E, Rogers MP, Ross OA, Samii A, Saunders-Pullman R, Schüle B, Schulte C, Scott WK, Tanner C, Tolosa E, Tomkins JE, Vilas D, Trojanowski JQ; 23andMe Research Team; Uitti R, Vance JM, Visanji NP, Wszolek ZK, Zabetian CP, Mirelman A, Giladi N, Orr Urtreger A, Cannon P, Fiske B, Foroud T. Lai D, et al. Among authors: mclean cy. Ann Neurol. 2021 Jul;90(1):76-88. doi: 10.1002/ana.26094. Epub 2021 May 17. Ann Neurol. 2021. PMID: 33938021 Free PMC article.
23 results