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Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first-in-human phase I study.
Clin Transl Sci. 2024 Apr;17(4):e13762. doi: 10.1111/cts.13762.
Clin Transl Sci. 2024.
PMID: 38591811
Free PMC article.
Clinical Trial.
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA.
Altarejos JY, et al. Among authors: gewitz ad.
Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22.
Sci Transl Med. 2023.
PMID: 37992152
Clinical Trial.
Item in Clipboard
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial.
Rosenson RS, Gaudet D, Ballantyne CM, Baum SJ, Bergeron J, Kershaw EE, Moriarty PM, Rubba P, Whitcomb DC, Banerjee P, Gewitz A, Gonzaga-Jauregui C, McGinniss J, Ponda MP, Pordy R, Zhao J, Rader DJ.
Rosenson RS, et al. Among authors: gewitz a.
Nat Med. 2023 Mar;29(3):729-737. doi: 10.1038/s41591-023-02222-w. Epub 2023 Mar 6.
Nat Med. 2023.
PMID: 36879129
Free PMC article.
Clinical Trial.
Item in Clipboard
Longitudinal Model-Based Biomarker Analysis of Exposure-Response Relationships in Adults with Pulmonary Tuberculosis.
Gewitz AD, Solans BP, Mac Kenzie WR, Heilig C, Whitworth WC, Johnson JL, Nsubuga P, Dorman S, Weiner M, Savic RM; Tuberculosis Trials Consortium of the Centers for Disease Control and Prevention.
Gewitz AD, et al.
Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0179420. doi: 10.1128/AAC.01794-20. Epub 2021 Jul 12.
Antimicrob Agents Chemother. 2021.
PMID: 34252302
Free PMC article.
Item in Clipboard
Differential Toxicity in Patients with and without DNA Repair Mutations: Phase I Study of Carboplatin and Talazoparib in Advanced Solid Tumors.
Dhawan MS, Bartelink IH, Aggarwal RR, Leng J, Zhang JZ, Pawlowska N, Terranova-Barberio M, Grabowsky JA, Gewitz A, Chien AJ, Moasser M, Kelley RK, Maktabi T, Thomas S, Munster PN.
Dhawan MS, et al. Among authors: gewitz a.
Clin Cancer Res. 2017 Nov 1;23(21):6400-6410. doi: 10.1158/1078-0432.CCR-17-0703. Epub 2017 Aug 8.
Clin Cancer Res. 2017.
PMID: 28790114
Clinical Trial.
Item in Clipboard
Relational grounding facilitates development of scientifically useful multiscale models.
Hunt CA, Ropella GE, Lam Tn, Gewitz AD.
Hunt CA, et al. Among authors: gewitz ad.
Theor Biol Med Model. 2011 Sep 27;8:35. doi: 10.1186/1742-4682-8-35.
Theor Biol Med Model. 2011.
PMID: 21951817
Free PMC article.
Review.
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