Podgrabinska S - Search Results

1

Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first-in-human phase I study.

Gewitz A, Mendell J, Wang Y, Harris C, Olenchock BA, Podgrabinska S, Zheng W, Zhao A, Pan H, Vanhoutte F, Davis JD. Gewitz A, et al. Among authors: podgrabinska s. Clin Transl Sci. 2024 Apr;17(4):e13762. doi: 10.1111/cts.13762. Clin Transl Sci. 2024. PMID: 38591811 Free PMC article. Clinical Trial.

2

Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.

Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA. Altarejos JY, et al. Among authors: podgrabinska s. Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992152 Clinical Trial.

3

Role of lymphatic vasculature in regional and distant metastases.

Podgrabinska S, Skobe M. Podgrabinska S, et al. Microvasc Res. 2014 Sep;95:46-52. doi: 10.1016/j.mvr.2014.07.004. Epub 2014 Jul 12. Microvasc Res. 2014. PMID: 25026412 Free PMC article. Review.

4

Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance.

Serasinghe MN, Missert DJ, Asciolla JJ, Podgrabinska S, Wieder SY, Izadmehr S, Belbin G, Skobe M, Chipuk JE. Serasinghe MN, et al. Among authors: podgrabinska s. Oncogene. 2015 Feb 12;34(7):857-67. doi: 10.1038/onc.2014.21. Epub 2014 Mar 10. Oncogene. 2015. PMID: 24608435 Free PMC article.

5

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses.

Das S, Sarrou E, Podgrabinska S, Cassella M, Mungamuri SK, Feirt N, Gordon R, Nagi CS, Wang Y, Entenberg D, Condeelis J, Skobe M. Das S, et al. Among authors: podgrabinska s. J Exp Med. 2013 Jul 29;210(8):1509-28. doi: 10.1084/jem.20111627. Epub 2013 Jul 22. J Exp Med. 2013. PMID: 23878309 Free PMC article.

6

Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases.

Das S, Ladell DS, Podgrabinska S, Ponomarev V, Nagi C, Fallon JT, Skobe M. Das S, et al. Among authors: podgrabinska s. Cancer Res. 2010 Mar 1;70(5):1814-24. doi: 10.1158/0008-5472.CAN-09-3675. Epub 2010 Feb 23. Cancer Res. 2010. PMID: 20179201 Free PMC article.

7

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism.

Podgrabinska S, Kamalu O, Mayer L, Shimaoka M, Snoeck H, Randolph GJ, Skobe M. Podgrabinska S, et al. J Immunol. 2009 Aug 1;183(3):1767-79. doi: 10.4049/jimmunol.0802167. Epub 2009 Jul 8. J Immunol. 2009. PMID: 19587009 Free PMC article.

8

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.

Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J. Shawber CJ, et al. Among authors: podgrabinska s. J Clin Invest. 2007 Nov;117(11):3369-82. doi: 10.1172/JCI24311. J Clin Invest. 2007. PMID: 17948123 Free PMC article.

9

Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype.

Grossmann C, Podgrabinska S, Skobe M, Ganem D. Grossmann C, et al. Among authors: podgrabinska s. J Virol. 2006 Jul;80(14):7179-85. doi: 10.1128/JVI.01603-05. J Virol. 2006. PMID: 16809323 Free PMC article.

10

Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2.

Roberts N, Kloos B, Cassella M, Podgrabinska S, Persaud K, Wu Y, Pytowski B, Skobe M. Roberts N, et al. Among authors: podgrabinska s. Cancer Res. 2006 Mar 1;66(5):2650-7. doi: 10.1158/0008-5472.CAN-05-1843. Cancer Res. 2006. PMID: 16510584

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